The effect of rate and dose of glucose infusion on the acute insulin response in man.
The effect of rate and dose of glucose infusion on the acute insulin response in man.
复制标题
葡萄糖输注速度和剂量对人体急性胰岛素反应的影响。
DOI：
--
复制
发表时间：
1976
影响因子：
5.8
通讯作者：
D. Porte
中科院分区：
文献类型：
--
作者：
Mei Chen;D. Porte
已经进行了两种类型的研究，以确定正常男性静脉注射葡萄糖后血浆葡萄糖浓度变化率对急性胰岛素反应幅度的重要性。当以不同的输注速率（1.67 g/min至66.7 g/min）给予等量的葡萄糖（20 g）时，发现急性胰岛素反应的幅度与速率成比例。当以相同的速率（1.67 g/min）给予不同剂量（5 g至20 g）时，急性胰岛素反应没有变化。当在0.3和3分钟内给予5 g葡萄糖时，产生次最大急性胰岛素反应，其仍然是速率依赖性的（5 g/0.3分钟时Δ峰IRI=35.5 +/- 5，5 g/3分钟时为21.8 +/- 3）。我们的结论是，人胰岛作为一个传感器的血糖浓度和血糖的变化率。胰岛对这两种现象的感知是确定急性胰岛素反应幅度的关键因素。
Two types of studies have been done to determine the importance of the rate of plasma glucose concentration change to the magnitude of the acute insulin response following an intravenous glucose injection in normal men. When an identical amount of glucose (20 g) was given at varying infusion rates (1.67 g/min to 66.7 g/min), the magnitude of the acute insulin response was found to be proportional to the rate. When various doses (5 g to 20 g) were given at the identical rate (1.67 g/min) the acute insulin response did not change. When 5 g of glucose was given in 0.3 and 3 minutes, a sub-maximal acute insulin response resulted which was still rate-dependent (delta peak IRI=35.5 +/- 5 at 5 g/0.3 minutes, 21.8 +/- 3 at 5 g/3 minutes). We have concluded that the human islet acts as a sensor for both the concentration of plasma glucose and the rate of change in plasma glucose. Islet perception of both these phenomena are critical factors in the determination of the magnitude of the acute insulin response.