Novelty seeking:: interaction between parental alcohol use and dopamine D4 receptor gene exon III polymorphism over 17 years
Novelty seeking:: interaction between parental alcohol use and dopamine D4 receptor gene exon III polymorphism over 17 years
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DOI：
10.1097/00041444-200506000-00010
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发表时间：
2005-06-01
影响因子：
0.9
通讯作者：
Keltikangas-Järvinen, L
中科院分区：
文献类型：
--
作者：
Lahti, J;Räikkönen, K;Keltikangas-Järvinen, L
最近的荟萃分析对多巴胺受体D4 （DRD4）基因多态性与求新性情之间的关系提出了质疑，并提出了该多态性与其他因素之间的相互作用。我们想测试父母在童年时期饮酒是否会调节后代多巴胺受体基因（DRD4）多态性对成年后寻求新奇的气质特征的影响。1980年和1983年，对儿童和青少年（n=2149）及其父母进行了以人群为基础的样本，调查了父母的酒精使用和养育方式。1997年，研究对象完成了“气质与性格量表”（Temperament and Character Inventory），并对150个子样本进行了DRD4外显子III多态性的基因分型。对于有父亲而不是母亲的参与者，在寻求新奇性评估前17年和/或14年的检查中报告更频繁饮酒或醉酒，观察到DRD4基因的短等位基因（两个或五个重复）与极高的寻求新奇性得分之间的关联。当父亲报告较少饮酒或醉酒时，基因型与追求新奇无关。在控制了性别、年龄和母亲抚养孩子的情况后，这种联系仍然存在。这些结果为寻求新颖性气质特征的基因-环境相互作用提供了初步信息，并可以部分解释DRD4多态性与寻求新颖性相关研究结果的异质性。(c) 2005年Lippincott Williams & Wilkins。
Recent meta-analyses have questioned the association between the dopamine receptor D4 (DRD4) gene polymorphism and the temperament trait of novelty seeking, and proposed an interaction between the polymorphism and other factors. We wanted to test whether parental alcohol use during childhood moderated the effect of an offspring dopamine receptor gene (DRD4) polymorphism on the temperament trait of novelty seeking in adulthood. A population-based sample of children and adolescents (n=2149) and their parents was examined in 1980 and 1983 on parental alcohol use and rearing practices. In 1997, study participants completed the Temperament and Character Inventory for the novelty-seeking temperament trait, and a subsample (n = 150) was genotyped for the DRD4 exon III polymorphism. For the participants with the father, but not the mother, reporting more frequent alcohol consumption or drunkenness in examinations 17 and/or 14 years before the novelty-seeking assessment, an association between the short (two- or five-repeat) alleles of the DRD4 gene and extremely high novelty-seeking scores was observed. When the father reported less frequent alcohol consumption or drunkenness, the genotype was not associated with novelty seeking. The association remained after controlling for sex, age, and maternal child-rearing. These results provide preliminary information on gene-environment interaction on the temperament trait of novelty seeking and may partly explain the heterogeneity of findings concerning the association between DRD4 polymorphisms and novelty seeking. (c) 2005 Lippincott Williams & Wilkins.