Identification of a highly divergent HIV type 2 and proposal for a change in HIV type 2 classification
Identification of a highly divergent HIV type 2 and proposal for a change in HIV type 2 classification
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DOI：
10.1089/0889222041217392
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发表时间：
2004-06-01
影响因子：
1.5
通讯作者：
Simon, F
中科院分区：
文献类型：
--
作者：
Damond, F;Worobey, M;Simon, F
我们报告了 2 型人类免疫缺陷病毒 (HIV-2) 96FR12034 高度分化毒株的完整基因组序列，该毒株是在法国从一名西非血统患者身上发现的。该谱系 H 仅代表 SIVsm 从猴向人转移的第三个确定实例，该 SIVsm 已产生致病性 HIV-2。由于 HIV-2 的不同“亚型”类似于 HIV-1 的不同组，因此我们建议根据 HIV 命名委员会的意见，对 HIV-2 亚型重新命名。此处确定的单毒株谱系 C 至 G 和 96FR12034 谱系仅应被视为假定群体，直到确定相关毒株以确认这些病毒在人群中的传播。
We report the complete genome sequence of a highly divergent strain of human immunodeficiency virus type 2 (HIV-2), 96FR12034, identified in France from a patient of West African origin. This lineage, H, represents only the third definitive instance of a monkey-to-human transfer of SIVsm that has given rise to pathogenic HIV-2. As the different "subtypes" of HIV-2 are analogous to the different groups of HIV-1 we propose that HIV-2 subtypes henceforth by renamed groups in agreement with the HIV Nomenclature Committee. The single-strain lineages C to G and the 96FR12034 lineage identified here should be considered only as putative groups until related strains are identified that confirm circulation of these viruses in the human population.