Odor Perception on the Two Sides of the Brain: Consistency Despite Randomness.

Odor Perception on the Two Sides of the Brain: Consistency Despite Randomness.
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大脑两侧的气味感知:尽管有随机性。

DOI:
10.1016/j.neuron.2018.04.004
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发表时间:
2018-05-16
期刊:
影响因子:
16.2
通讯作者:
Abbott LF
Abbott LF
中科院分区:
医学1区
文献类型:
--
作者:
Schaffer ES;Stettler DD;Kato D;Choi GB;Axel R;Abbott LF

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梨状皮质的神经元接受来自肾小球随机集合的输入,导致缺乏嗅球的刻板组织的气味表征。我们已经在体内进行了光学成像和数学建模,以证明相关性保留在从球到梨状皮质的转换,一个功能的概括跨气味。随机连通性也意味着,对特定气味的梨状波表征在不同个体之间以及单个个体的大脑半球之间会有所不同。我们发现,这些不同的表示,但可以支持一致的协议,气味质量在一系列的气味。我们的模型还表明,虽然气味的歧视和分类需要的神经元比居住在梨状皮质少得多,一致的泛化可能需要完整的梨状神经元。从嗅球到梨状核的随机连接意味着气味的表征在不同的皮层中会有所不同。Schaffer等人在一个模型中证明,关于气味质量的一致协议发生,但需要完整的梨状神经元。
Neurons in piriform cortex receive input from a random collection of glomeruli, resulting in odor representations that lack the stereotypic organization of the olfactory bulb. We have performed in vivo optical imaging and mathematical modeling to demonstrate that correlations are retained in the transformation from bulb to piriform cortex, a feature essential for generalization across odors. Random connectivity also implies that the piriform representation of a given odor will differ among different individuals and across brain hemispheres in a single individual. We show that these different representations can nevertheless support consistent agreement about odor quality across a range of odors. Our model also demonstrates that, whereas odor discrimination and categorization require far fewer neurons than reside in piriform cortex, consistent generalization may require the full complement of piriform neurons. Random connectivity from the olfactory bulb to piriform implies that the representation of odors will differ in different cortices. Schaffer et al. demonstrate in a model that consistent agreement about odor quality occurs but requires the full complement of piriform neurons.
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