Odor Perception on the Two Sides of the Brain: Consistency Despite Randomness.
Odor Perception on the Two Sides of the Brain: Consistency Despite Randomness.
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大脑两侧的气味感知:尽管有随机性。
DOI:
10.1016/j.neuron.2018.04.004
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发表时间:
2018-05-16
期刊:
影响因子:
16.2
通讯作者:
Abbott LF
中科院分区:
文献类型:
--
作者:
Schaffer ES;Stettler DD;Kato D;Choi GB;Axel R;Abbott LF
Neurons in piriform cortex receive input from a random collection of glomeruli, resulting in odor representations that lack the stereotypic organization of the olfactory bulb. We have performed in vivo optical imaging and mathematical modeling to demonstrate that correlations are retained in the transformation from bulb to piriform cortex, a feature essential for generalization across odors. Random connectivity also implies that the piriform representation of a given odor will differ among different individuals and across brain hemispheres in a single individual. We show that these different representations can nevertheless support consistent agreement about odor quality across a range of odors. Our model also demonstrates that, whereas odor discrimination and categorization require far fewer neurons than reside in piriform cortex, consistent generalization may require the full complement of piriform neurons. Random connectivity from the olfactory bulb to piriform implies that the representation of odors will differ in different cortices. Schaffer et al. demonstrate in a model that consistent agreement about odor quality occurs but requires the full complement of piriform neurons.
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影响因子:
16.2
作者:
Litwin-Kumar A;Harris KD;Axel R;Sompolinsky H;Abbott LF
通讯作者:
Abbott LF
DOI:
10.1073/pnas.1117491109
发表时间:
2012-04-03
影响因子:
11.1
作者:
Ma, Limei;Qiu, Qiang;Yu, C. Ron
通讯作者:
Yu, C. Ron
DOI:
10.1523/jneurosci.2753-12.2013
发表时间:
2013-02-27
期刊:
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子:
--
作者:
Barak O;Rigotti M;Fusi S
通讯作者:
Fusi S
影响因子:
64.8
作者:
Ghosh, Sulagna;Larson, Stephen D.;Baldwin, Kristin K.
通讯作者:
Baldwin, Kristin K.
影响因子:
1.9
作者:
OJA, E
通讯作者:
OJA, E