Validity of single variables and indices to measure disease activity in rheumatoid arthritis.
Validity of single variables and indices to measure disease activity in rheumatoid arthritis.
复制标题
测量类风湿关节炎疾病活动性的单一变量和指数的有效性。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
van de Putte Lb
中科院分区：
文献类型：
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作者：
van der Heijde Dm;M. van'tHof;Van Riel Pl;van de Putte Lb
：我们比较了我们诊所二线药物之间2项试验中几个变量的敏感性。在一项比较柳氮磺胺吡啶与羟氯喹的试验中，发现在里奇评分、肿胀关节数、疾病活动度评分（DAS）、身体残疾和放射学损伤方面，柳氮磺胺吡啶有显著差异。这不能通过压痛关节的数量、患者的整体评估、疼痛、晨僵或红细胞沉降率（ESR）来确定。在一项比较甲氨蝶呤和硫唑嘌呤的试验中，通过疼痛、DAS、ESR、C反应蛋白、血红蛋白和血小板变量，可以发现甲氨蝶呤有显著差异;而通过里奇评分、压痛关节数和肿胀关节数，则没有显著差异。将各种验证程序的结果结合起来，可以得出变量的相对质量。
: We compared the sensitivity of several variables in 2 trials between second-line agents in our clinic. In a trial comparing sulfasalazine with hydroxychloroquine significant differences were found in favor of sulfasalazine by the Ritchie score, number of swollen joints, disease activity score (DAS), physical disability and radiographic damage. This could not be determined by number of tender joints, patient's global assessment, pain, morning stiffness, or erythrocyte sedimentation rate (ESR). In a trial comparing methotrexate with azathioprine significant differences could be found in favor of methotrexate by the variables of pain, DAS, ESR, C-reactive protein, hemoglobin and thrombocytes; not by Ritchie score, number of tender joints and number of swollen joints. Combining the results of the various validation procedures leads to relative quality of the variables.