A toxic mutant huntingtin species is resistant to selective autophagy
A toxic mutant huntingtin species is resistant to selective autophagy
复制标题
有毒突变亨廷顿物种对选择性自噬具有抵抗力
DOI：
10.1038/nchembio.2461
复制
发表时间：
2017-11-01
影响因子：
14.8
通讯作者：
Lu, Boxun
中科院分区：
文献类型：
--
作者：
Fu, Yuhua;Wu, Peng;Lu, Boxun
Protein misfolding is a common theme in neurodegenerative disorders including Huntington's disease (HD). The HD-causing mutant huntingtin protein (mHTT) has an expanded polyglutamine (polyQ) stretch that may adopt multiple conformations, and the most toxic of these is the one recognized by antibody 3B5H10. Here we show that the 3B5H10-recognized mHTT species has a slower degradation rate due to its resistance to selective autophagy in human cells and brains, revealing mechanisms of its higher toxicity.
