Can augmentation index substitute aortic pulse wave velocity in the assessment of central arterial stiffness in type 1 diabetes?
Can augmentation index substitute aortic pulse wave velocity in the assessment of central arterial stiffness in type 1 diabetes?
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DOI：
10.1007/s00592-012-0433-y
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发表时间：
2012-12-01
影响因子：
3.8
通讯作者：
Gonzalez-Clemente, Jose-Miguel
中科院分区：
文献类型：
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作者：
Llaurado, Gemma;Simo, Rafael;Gonzalez-Clemente, Jose-Miguel
本研究的目的是测试在测量1型糖尿病患者的动脉僵硬度（AS）时，心率调整的增强指数（AIx@HR75）是否可以用作主动脉脉搏波速度（aPWV）的替代品。68例1型糖尿病患者和68名年龄和性别匹配的对照进行了评估。采用压平眼压法测定aPWV和AIx@HR75。与对照组相比，1型糖尿病受试者的aPWV较高，但在AIx@HR75方面未发现组间差异[男性：10.75%（2.63-20.75）vs. 8.25%（4.00-11.38）; p = 0.462。女性：20.75%（5.00-30.16）vs. 14.50%（11.38-22.16）; p = 0.418]。在单变量分析中，两组中aPWV与AIx@HR75呈正相关（1型：r = 0.340，p = 0.005;健康受试者：r = 0.451，p < 0.001）。然而，在多变量模型中调整心血管危险因素后，AIx@HR75与aPWV无关（1型：p = 0.342;健康受试者：p = 0.976）。我们的研究结果表明，AIx@HR75不应被用作aPWV测量1型糖尿病AS的替代品。
The aim of this study was to test whether the augmentation index adjusted for heart rate (AIx@HR75) can be used as a substitute for aortic pulse wave velocity (aPWV) in the measurement of arterial stiffness (AS) in type 1 diabetes. Sixty-eight patients with type 1 diabetes and 68 age- and sex-matched controls were evaluated. AS was assessed by aPWV and AIx@HR75 using applanation tonometry. Subjects with type 1 diabetes had higher aPWV compared to controls, but no differences were found between groups regarding AIx@HR75 [men: 10.75 % (2.63-20.75) vs. 8.25 % (4.00-11.38); p = 0.462. Women: 20.75 % (5.00-30.16) vs. 14.50 % (11.38-22.16); p = 0.418]. In univariate analyses, aPWV correlated positively with AIx@HR75 in both groups (type 1: r = 0.340, p = 0.005; healthy subjects: r = 0.451, p < 0.001). However, AIx@HR75 was not associated with aPWV after adjustment for cardiovascular risk factors in multivariate models (type 1: p = 0.342; healthy subjects: p = 0.976). Our findings suggest that AIx@HR75 should not be used as a substitute for aPWV for measuring AS in type 1 diabetes.