Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats.
Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats.
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DOI：
10.1111/adb.12059
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发表时间：
2014-09
影响因子：
3.4
通讯作者：
Gilpin NW
中科院分区：
文献类型：
--
作者：
Kallupi M;Vendruscolo LF;Carmichael CY;George O;Koob GF;Gilpin NW
Electrophysiological data suggest a dual role of Y2 receptors (Y2Rs) as autoreceptors regulating neuropeptide Y release and heteroceptors regulating gamma-aminobutyric acid release in the central amygdala (CeA). Here, we report that neither systemic (JNJ-31020028) nor intra-CeA (BIIE0246) Y2R antagonism altered operant alcohol responding by alcohol-dependent or non-dependent rats. Conversely, BIIE0246 in the CeA reduced anxiety-like behavior in alcohol-dependent and alcohol-naïve rats. The finding that Y2R antagonism reduces anxiety-like behavior but not alcohol drinking suggests that these two effects may occur via different functions of the Y2R (e.g. autoreceptor versus heteroceptor function).
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影响因子：
8.2
作者：
Gilpin, Nicholas W.;Roberto, Marisa
通讯作者：
Roberto, Marisa
DOI：
10.1152/ajpheart.1997.273.4.h1737
发表时间：
1997-10-01
影响因子：
4.8
作者：
Chen, XL;DiMaggio, DA;Westfall, TC
通讯作者：
Westfall, TC
影响因子：
2.5
作者：
Rimondini, R;Thorsell, A;Heilig, M
通讯作者：
Heilig, M
影响因子：
3.4
作者：
Shoblock, James R.;Welty, Natalie;Bonaventure, Pascal
通讯作者：
Bonaventure, Pascal
DOI：
10.1523/jneurosci.0430-10.2010
发表时间：
2010-05-05
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Tasan RO;Nguyen NK;Weger S;Sartori SB;Singewald N;Heilbronn R;Herzog H;Sperk G
通讯作者：
Sperk G