The characterization of human cortical bone microdamage by nuclear magnetic resonance
The characterization of human cortical bone microdamage by nuclear magnetic resonance
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DOI：
10.1088/0957-0233/16/3/006
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发表时间：
2005-03-01
影响因子：
2.4
通讯作者：
Nicolella, DP
中科院分区：
文献类型：
--
作者：
Ni, QW;Nicolella, DP
核磁共振（NMR）自旋-自旋（T-2）弛豫技术已被描述用于检测损伤后的人皮质骨组织的微观结构变化。该技术被应用于量化骨孔隙率的明显变化，导致循环载荷引起的皮质骨微损伤。使用质子弛豫数据的校准NMR流体体积除以总骨体积来确定总骨孔隙率。从皮质骨标本损伤前和损伤后获得的核磁共振孔隙率与目前可用的，但破坏性的组织形态测定确定的孔隙率进行比较。说明了利用核磁共振T-2弛豫技术进行骨微损伤研究的优势。T-2弛豫数据可以反演为T-2弛豫分布。在表面弛豫常数已知的情况下，反演T-2弛豫分布可以转化为弛豫时间越长，孔隙越大的孔径分布。结果表明，用2MHz或27MHz核磁共振质子共振，得到类似的表面弛豫常数。它还表明，NMR T-2弛豫数据是敏感的变化所造成的创建微损伤皮质骨，这可以被解释为一个有效的增加骨孔隙度。这些结果表明，通过该技术检测皮质骨微损伤是可能的。
A nuclear magnetic resonance (NMR) spin-spin (T-2) relaxation technique has been described for detecting post-damage microstructural changes in human cortical bone tissue. The technique is applied to quantify apparent changes in bone porosity resulting from cyclic loading induced microdamage in cortical bone. Overall bone porosity is determined using the calibrated NMR fluid volume from the proton relaxation data divided by the overall bone volume. The NMR porosities obtained from cortical bone specimens pre- and post-damage are compared with the currently available but destructive histomorphometrically determined porosity. The advantages of using NMR T-2 relaxation techniques for bone microdamage are illustrated. The T-2 relaxation data can be inverted to T-2 relaxation distribution. The inversion T-2 relaxation distribution can then be transfon-ned to a pore-size distribution with the longer relaxation times corresponding to larger pores if the surface relaxivity constant is known. It is shown that by using NMR 2 MHz or 27 MHz proton resonance, similar surface relaxivity constants are obtained. It is also demonstrated that the NMR T-2 relaxation data are sensitive to changes resulting from the creation of microdamage in cortical bone, which can be interpreted as an effective increase in bone porosity. These results indicate that the detection of cortical bone microdamage is possible by this technique.