Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight
Maternal lipid levels across pregnancy impact the umbilical cord blood lipidome and infant birth weight
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DOI：
10.1038/s41598-020-71081-z
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发表时间：
2020-08-26
影响因子：
4.6
通讯作者：
Burant, Charles F.
中科院分区：
文献类型：
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作者：
LaBarre, Jennifer L.;Puttabyatappa, Muraly;Burant, Charles F.
在怀孕期间发生的主要代谢变化使母亲能够提供足够的营养来支持婴儿发育，影响出生体重（BW）和潜在的肥胖和心脏代谢疾病的长期风险。我们对孕妇妊娠期间脂质组的动态变化进行了分类，并确定了与Fenton BW -score和脐带血（CB）脂质组相关的脂质。脂质组学对106例母婴对孕早期母体血浆（M1）、分娩母体血浆（M3）和CB血浆进行了检测。母鼠和弓形虫脂质组的变化与长链多不饱和脂肪酸（PUFA）、溶血磷脂酰胆碱（LysoPC）和溶血磷脂酰乙醇胺（LysoPE）向弓形虫的选择性转运一致。部分相关网络显示脂质组在M1、M3和CB处的相关性存在波动，表明脂质代谢存在差异。采用线性模型，CB中的LysoPC和LysoPE组与体重呈正相关。含有甘油三酯（TG）和磷脂的M1 PUFA与CB LysoPC和LysoPE种类以及CB多不饱和TG总量相关。这些结果表明，妊娠早期母体脂质水平影响子代脂肪组及其与体重的关系，表明有机会调节母体饮食并改善后代的长期心脏代谢健康。
Major alterations in metabolism occur during pregnancy enabling the mother to provide adequate nutrients to support infant development, affecting birth weight (BW) and potentially long-term risk of obesity and cardiometabolic disease. We classified dynamic changes in the maternal lipidome during pregnancy and identified lipids associated with Fenton BW z-score and the umbilical cord blood (CB) lipidome. Lipidomics was performed on first trimester maternal plasma (M1), delivery maternal plasma (M3), and CB plasma in 106 mother-infant dyads. Shifts in the maternal and CB lipidome were consistent with the selective transport of long-chain polyunsaturated fatty acids (PUFA) as well as lysophosphatidylcholine (LysoPC) and lysophosphatidylethanolamine (LysoPE) species into CB. Partial correlation networks demonstrated fluctuations in correlations between lipid groups at M1, M3, and CB, signifying differences in lipid metabolism. Using linear models, LysoPC and LysoPE groups in CB were positively associated with BW. M1 PUFA containing triglycerides (TG) and phospholipids were correlated with CB LysoPC and LysoPE species and total CB polyunsaturated TGs. These results indicate that early gestational maternal lipid levels influence the CB lipidome and its relationship with BW, suggesting an opportunity to modulate maternal diet and improve long-term offspring cardiometabolic health.