Pathogenesis of Type 2 Diabetes Mellitus
Pathogenesis of Type 2 Diabetes Mellitus
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DOI：
10.5772/59183
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发表时间：
2015-04
期刊：
影响因子：
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通讯作者：
F. Alsaraj
中科院分区：
文献类型：
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作者：
F. Alsaraj
2型糖尿病(T2 DM)的自然病史已经在多个人群中得到了很好的描述。T2 DM患者从父母那里遗传了基因，使他们的组织对胰岛素产生抵抗。肌肉和肝脏的胰岛素抵抗(IR)和β细胞衰竭是T2 DM发展过程中的核心病理生理缺陷。年龄、基因、IR、脂毒性、糖毒性、淀粉样蛋白沉积和异常胰岛素是导致β细胞进行性功能障碍的因素。胰岛素分泌的进行性下降、胰腺β细胞质量和功能的减少以及IR的存在将有助于将血糖异常的状态从正常转变为空腹血糖受损、糖耐量受损并最终导致显性糖尿病[1]。
The natural history of type 2 diabetes (T2DM) has been well described in multiple populations. Patients with T2DM have inherited genes from parents that make their tissues resistant to insulin. Insulin resistance (IR) in muscle and liver and β-cell failure represent the core pathophysiologic defects in development of T2DM. Age, genes, IR, lipotoxicity, glucotoxicity, amyloid deposition and abnormal incretin are factors playing a role in progressive β-cells dysfunction. The progressive decline in insulin secretion, decrease of the pancreatic βcell mass and function and the presence of IR will contribute in changing the state of the dysgly‐ cemia from normal to, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and end with overt diabetes [1].