Alcohol Has a Dose-Related Effect on Parasympathetic Nerve Activity During Sleep
Alcohol Has a Dose-Related Effect on Parasympathetic Nerve Activity During Sleep
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DOI：
10.1111/j.1530-0277.2011.01558.x
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发表时间：
2011-11-01
影响因子：
3.2
通讯作者：
Shimizu, Tetsuo
中科院分区：
文献类型：
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作者：
Sagawa, Yohei;Kondo, Hideaki;Shimizu, Tetsuo
背景资料：本研究的目的是确定急性影响乙醇的睡眠和心率变异性（HRV）在sleep.Methods之间的关系：10名健康男性大学生参加了这项研究。以0（对照）、0.5（低剂量：LD）或1.0 g（高剂量：HD）纯乙醇/kg体重的剂量给予每名受试者酒精饮料。所有实验均以3周间隔进行。在实验当天，将霍尔特心电图附在受试者身上24小时，并指示受试者在睡觉前100分钟饮用上述剂量的酒精饮料;然后进行8小时的多导睡眠描记术。采用最大熵法对心率变异性进行功率谱分析，计算低频（LF：0.04 ~ 0.15 Hz）和高频（HF：0.15 ~ 0.4 Hz）分量沿着LF/HF比值。较高剂量的乙醇也增加了LF/HF的比率与测量的比率的control group.Conclusions：急性乙醇摄入抑制副交感神经的活动，并导致在睡眠期间的交感神经活动的优势，在剂量依赖性的方式。这项研究的结果表明，乙醇干扰睡眠的恢复功能。
Background: The aim of this study was to identify the acute effects of ethanol on the relationship between sleep and heart rate variability (HRV) during sleep.Methods: Ten healthy male university students were enrolled in this study. An alcoholic beverage was given to each subject at a dosage of 0 (control), 0.5 (low dose: LD), or 1.0 g (high dose: HD) of pure ethanol/kg of body weight. All experiments were performed at 3-week intervals. On the day of the experiment, a Holter electrocardiogram was attached to the subject for a 24-hour period, and the subject was instructed to drink the above-described dosage of alcoholic beverage 100 minutes before going to bed; polysomnography was then performed for 8 hours. Power spectral analysis of the HRV was performed using the maximum entropy method, and the low-(LF: 0.04 to 0.15 Hz) and high-frequency (HF: 0.15 to 0.4 Hz) components along with LF/HF ratio were calculated.Results: As alcohol consumption increased, the heart rate increased and the spectral power of HRV measured at each frequency range decreased. Higher doses of ethanol also increased the LF/HF ratio compared with the measured ratio of the control group.Conclusions: Acute ethanol intake inhibits parasympathetic nerve activity and results in predominance of sympathetic nerve activity during sleep, in a dosage-dependent manner. The results of this study suggest that ethanol interferes with the restorative functions of sleep.