Constituents of the root of Anemone tomentosa
Constituents of the root of Anemone tomentosa
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DOI：
10.1007/s12272-011-0707-x
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发表时间：
2011-08
影响因子：
6.7
通讯作者：
Haobin Hu;Xu-dong Zheng;Y. Jian;Jian-xin Liu;Jihua Zhu
中科院分区：
文献类型：
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作者：
Haobin Hu;Xu-dong Zheng;Y. Jian;Jian-xin Liu;Jihua Zhu
一个新的二萜糖苷，毛蕊糖苷I(1)，连同11个已知化合物，包括4种香豆素，4,5-二甲氧基-7-甲基香豆素(2),4,7-二甲氧基-5-甲基香豆素(3)，异毛蕊糖苷(4)和毛蕊糖苷(5)，以及7种三萜，齐墩果酸(6)，齐墩果酸3- o -α- l-阿拉伯葡萄糖苷(7)，齐墩果酸3- o -β- d -半乳糖糖苷-(1→3)-β- d -葡萄糖苷(8)，异黄酮苷3- o -α- l-阿拉伯葡萄糖苷(9)，白桦树酸（10），从银莲花根乙醇提取物中分离得到18-羟基熊果酸（11）和2α，3β，23-三羟基-12-烯-28-熊果酸（12），并用波谱分析方法对其化学结构进行了鉴定。采用琼脂圆盘扩散法测定化合物1 ~ 12的抑菌活性。并对其抗1,1-二苯基-2-苦味酰肼（DPPH）的活性进行了评价。
A new diterpene glycoside, tomentoside I (1), along with eleven known compounds, including the four coumarins, 4,5-dimethoxyl-7-methylcoumarin (2), 4,7-dimethoxyl-5-methylcoumarin (3), isofraxidin (4) and fraxidin (5) as well as the seven triterpenoids, oleanolic acid (6), oleanolic acid 3-O-α-L-arabinopyranoside (7), oleanolic acid 3-O-β-D-galactopyranosyl-(1→3)-β-D-glucopyranoside (8), hederagenin 3-O-α-L-arabinopyranoside (9), betulinic acid (10), 18-hydroxyursolic acid (11) and 2α,3β,23-trihydroxyurs-12-en-28-oic acid (12) were isolated from the ethanolic extract of the root ofAnemone tomentosaand their chemical structures were elucidated by spectroscopic methods. The antimicrobial activities of compounds1–12were measured using the agar disc-diffusion method. Also, their antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) were evaluated.