Ghrelin, adiponectin, and leptin do not predict long-term changes in weight and body mass index in older adults: Longitudinal analysis of the Rancho Bernardo cohort
Ghrelin, adiponectin, and leptin do not predict long-term changes in weight and body mass index in older adults: Longitudinal analysis of the Rancho Bernardo cohort
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DOI：
10.1093/aje/kwi338
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发表时间：
2005-12-15
影响因子：
5
通讯作者：
Barrett-Connor, E
中科院分区：
文献类型：
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作者：
Langenberg, C;Bergstrom, J;Barrett-Connor, E
在横断面研究中，生长激素释放肽、瘦素和脂联素与体型相关;目前尚不清楚这些激素是否能预测体型的长期变化。采用多水平模型研究空腹血清激素与体重和体重指数变化之间的关系，空腹血清激素是在基线（1984-1987年）收集的样本中测量的，测量对象为698名男性和619名女性（60-91岁），体重和体重指数变化是在长达18年（中位数，4.7年）的随访期内反复评估的。生长激素释放肽增加一个标准差，基线体重降低-1.5 kg，脂联素增加一个标准差，基线体重降低-3.3 kg，男性和女性相似。对于瘦素，男性基线体重增加12.1 kg，而女性基线体重增加5.7 kg（性别交互作用p
Ghrelin, leptin, and adiponectin are associated with body size in cross-sectional studies; it is unknown whether these hormones predict long-term changes in body size. Multilevel models were used to study associations between fasting serum hormones, measured in 698 men and 619 women (60-91 years) in samples collected at baseline (1984-1987), and changes in weight and body mass index, assessed repeatedly over a follow-up period of up to 18 years (median, 4.7 years). Baseline weight was -1.5 kg lower for a one-standard-deviation increment in ghrelin and -3.3 kg lower for a one-standard-deviation increment in adiponectin, similar in men and women. For leptin, baseline weight was 12.1 kg higher for a one-standard-deviation increment in men, compared with 5.7 kg in women (sex-interaction p