Evolution of mammals and their gut microbes
Evolution of mammals and their gut microbes
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DOI：
10.1126/science.1155725
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发表时间：
2008-06-20
期刊：
影响因子：
56.9
通讯作者：
Gordon, Jeffrey I.
中科院分区：
文献类型：
--
作者：
Ley, Ruth E.;Hamady, Micah;Gordon, Jeffrey I.
哺乳动物是宏基因组的，因为它们不仅由自己的基因互补物组成，而且还由所有与其相关的微生物的基因互补物组成。为了了解哺乳动物及其土著微生物群落的共同进化，我们对来自人类粪便微生物群和生活在两个动物园和野生环境中的59种其他哺乳动物物种的细菌16 S核糖体RNA基因序列进行了基于网络的分析。结果表明，宿主饮食和繁殖都影响细菌多样性，从食肉动物到杂食动物再到草食动物;细菌群落与宿主共多样化;生活在现代生活方式下的人类肠道微生物群是典型的杂食灵长类动物。
Mammals are metagenomic in that they are composed of not only their own gene complements but also those of all of their associated microbes. To understand the coevolution of the mammals and their indigenous microbial communities, we conducted a network- based analysis of bacterial 16S ribosomal RNA gene sequences from the fecal microbiota of humans and 59 other mammalian species living in two zoos and in the wild. The results indicate that host diet and phylogeny both influence bacterial diversity, which increases from carnivory to omnivory to herbivory; that bacterial communities codiversified with their hosts; and that the gut microbiota of humans living a modern life- style is typical of omnivorous primates.