Regulation of neuron numbers in Xenopus laevis: Effects of hormonal manipulation altering size at metamorphosis
Regulation of neuron numbers in Xenopus laevis: Effects of hormonal manipulation altering size at metamorphosis
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非洲爪蟾神经元数量的调节：激素控制改变变态大小的影响
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
P. Grobstein
中科院分区：
文献类型：
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作者：
D. G. Sperry;P. Grobstein
在0.01%的6 - n -丙基- 2 -硫脲嘧啶（PTU）溶液中饲养的非洲爪蟾蝌蚪在幼虫期发育受阻，其中54只蝌蚪的体型继续增加。当从PTU的影响中释放出来时，它们蜕变成比未治疗的兄弟姐妹大得多的青蛙。利用这种大小差异来检验神经元数量与神经元细胞死亡期间突触后目标大小相匹配的假设，我们测量了PTU治疗和未治疗的66期青蛙变形的以下数据：腰椎外侧运动柱（L - LMC）运动神经元数量和平均核横截面积；胸腰椎背根神经节（DRG）细胞数和平均核横截面积；以及两条有代表性的大腿肌肉的肌纤维数量。我们还对未处理和PTU处理的54期蝌蚪进行了神经元数量和细胞大小的测量。
Xenopus laevis tadpoles reared in a 0.01% solution of 6‐n‐propyl‐2‐thiouracil (PTU) are blocked in their development at larval stage 54 out continue to increase in size. When released from the effects of PTU they metamorphose into frogs of sizes significantly larger than those of their untreated siblings. Using this size difference to examine the hypothesis that neuron numbers are matched to the size of their postsynaptic targets during neuronal cell death, we measured the following on stage 66 frogs metamorphosing from PTU‐treated and untreated tadpoles: lumbar lateral motor column (L‐LMC) motoneuron number and mean nuclear cross‐sectional area; thoracic and lumbar dorsal root ganglion (DRG) cell number and mean nuclear cross‐sectional area; and muscle fiber number in two representative thigh muscles. A few measurements of neuron number and cell size were also made on untreated and PTU‐treated stage 54 tadpoles.
运动神经元组织发生和肢体神经支配的发展。
影响因子：
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作者：
Hollyday,M
通讯作者：
Hollyday,M