Clinical and virological characterization of persistent human infection with simian foamy viruses
Clinical and virological characterization of persistent human infection with simian foamy viruses
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DOI：
10.1089/aid.2007.0104
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发表时间：
2007-11-01
影响因子：
1.5
通讯作者：
Chapman, Louisa E.
中科院分区：
文献类型：
--
作者：
Boneva, Roumiana S.;Switzer, William M.;Chapman, Louisa E.
职业性暴露于非人灵长类动物（NHP）的人员可持续感染猴泡沫病毒（SFV）。人畜共患SFV感染的临床意义和人传人尚不清楚。7名SFV感染的男性回答了年度结构化访谈，并提供了全血，口腔和泌尿生殖道标本进行研究。对妻子进行SFV感染检测。通过PCR在感染男性的PBMC中一致地检测到前病毒DNA，而在口腔或泌尿生殖道样本中不一致。SFV很少从他们的PBMCs和咽拭子中培养出来。尽管如此，以及长期的亲密接触（中位数20年），妻子们都是SFV阴性。大多数参与者报告了非特异性症状和衰老常见的疾病。然而，2例轻度血小板减少症患者中有1例出现临床无症状的非进展性单克隆自然杀伤细胞淋巴细胞增多症，与SFV的关系尚不清楚。所有参与者在1988年之前与NHP一起工作，使用粘膜皮肤保护不一致; 57%的人描述了涉及感染NHP物种的经皮损伤。SFV可能通过经皮和粘膜接触NHP体液传播给人类。有限的随访尚未发现SFV相关疾病和人类间的继发性传播。
Persons occupationally exposed to nonhuman primates ( NHPs) can be persistently infected with simian foamy virus (SFV). The clinical significance and person-to-person transmissibility of zoonotic SFV infection is unclear. Seven SFV-infected men responded to annual structured interviews and provided whole blood, oral, and urogenital specimens for study. Wives were tested for SFV infection. Proviral DNA was consistently detected by PCR in PBMCs of infected men and inconsistently in oral or urogenital samples. SFV was infrequently cultured from their PBMCs and throat swabs. Despite this and a long period of intimate exposure ( median 20 years), wives were SFV negative. Most participants reported nonspecific symptoms and diseases common to aging. However, one of two persons with mild thrombocytopenia had clinically asymptomatic non-progressive, monoclonal natural killer cell lymphocytosis of unclear relationship to SFV. All participants worked with NHPs before 1988 using mucocutaneous protection inconsistently; 57% described percutaneous injuries involving the infecting NHP species. SFV likely transmits to humans through both percutaneous and mucocutaneous exposures to NHP body fluids. Limited follow-up has not identified SFV-associated illness and secondary transmission among humans.