Metabolism of lysine in rat liver.
Metabolism of lysine in rat liver.
复制标题
赖氨酸在大鼠肝脏中的代谢。
DOI：
10.1016/0006-291x(67)90547-5
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发表时间：
1967
影响因子：
3.1
通讯作者：
T. Yamamura
中科院分区：
文献类型：
--
作者：
K. Higashino;M. Fujioka;T. Aoki;T. Yamamura
以前已经证明，在α-酮戊二酸存在下，线粒体中的赖氨酸被降解，在这种条件下，糖胺积累[1]。α-酮戊二酸对赖氨酸的分解和糖胺的形成是必需的，这表明在哺乳动物的肝脏中，赖氨酸的代谢是通过在酵母(2-6)中其生物合成所描述的反应序列的颠倒来进行的。本报告描述了糖胺在线粒体中进一步代谢为α-氨基己二酸，该反应需要NAD而不是NADP。
It was shown previously that lysine was degraded in the mitochondria in the presence of α-ketoglutarate and, under these conditions, saccharopine accumulated (1). The obligatory requirement of α-ketoglutarate for lysine breakdown as well as for saccharopine formation suggest that lysine is metabolized, in mammalian liver, by a reversal of reaction sequence described for its biosynthesis in yeast (2–6).The present report describes that saccharopine is further metabolized to α-aminoadipic acid in the mitochondria and that NAD rather than NADP is required in this reaction.