Prenatal blockade of androgen receptors reduces the number of intromissions needed to induce conditioned place preference after paced mating in female rats
Prenatal blockade of androgen receptors reduces the number of intromissions needed to induce conditioned place preference after paced mating in female rats
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DOI：
10.1016/j.pbb.2005.06.011
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发表时间：
2005-08-01
影响因子：
3.6
通讯作者：
Paredes, RG
中科院分区：
文献类型：
--
作者：
Domínguez-Salazar, E;Camacho, FJ;Paredes, RG
发情的雌性大鼠调节它们的性交速度来控制宫颈/阴道刺激的频率。接受至少10次有节奏的引入的雌性会形成一种奖励状态，通过条件位置偏好（CPP）来评估，而没有进行性交接触的雌性则不会产生CPP。我们想知道雄激素受体的阻断是否可以改变有节奏交配过程中产生CPP所需的插入数量。怀孕的雌性从怀孕第12天开始每天注射雄激素受体拮抗剂氟他胺，直到幼崽出生。当成年时，雌性产前暴露于氟他胺或对照物，卵巢切除和激素启动，以评估是否有节奏和无节奏交配诱发CPP。产前氟他胺治疗对全身注射吗啡的女性发生CPP的能力没有影响。氟他胺治疗的雌性在性接触中发生CPP，比对照组的雌性更少。当不允许女性在性接触中踱步时，没有观察到对条件反射的影响。结果表明，存在与奖励状态诱导相关的宫颈/阴道刺激阈值，并且可以通过产前阻断雄激素受体来降低该阈值。(c) 2005爱思唯尔公司版权所有。
Estrous female rats pace their coital contacts to control the rate of cervical/vaginal stimulation. Females that receive at least 10 paced intromissions develop a reward state, evaluated by conditioned place preference (CPP), whereas females that do not pace their coital contacts do not develop CPP. We asked if the blockade of androgen receptors could modify the number of intromissions needed during paced mating to develop CPP. Pregnant females received daily injections of the androgen receptor antagonist flutamide from day 12 of pregnancy until pups were born. When adults, females exposed prenatally to flutamide or vehicle were ovariectornized and hormonally primed to evaluate if paced and non-paced mating induced CPP. The prenatal flutamide treatment did not affect the capacity of females to develop CPP to a systemic morphine injection. Flutamide-treated females that paced their sexual contacts developed CPP with fewer intromissions than control females. No effect on conditioning was observed when females were not allowed to pace their sexual contacts. The results suggest the existence of a threshold of cervical/vaginal stimulation that correlates with the induction of a reward state and that this threshold can be reduced by prenatal blockade of androgen receptors. (c) 2005 Elsevier Inc. All rights reserved.