Characterization of early hepatic injury in HCV-negative recipients of HCV-infected kidneys.
Characterization of early hepatic injury in HCV-negative recipients of HCV-infected kidneys.
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HCV 感染肾脏的 HCV 阴性受者早期肝损伤的特征。
DOI：
10.1111/ctr.13494
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发表时间：
2019
影响因子：
2.1
通讯作者：
Goldberg,DavidS
中科院分区：
文献类型：
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作者：
Mazur,RafalD;Abt,PeterL;Blumberg,EmilyA;Bloom,RoyD;Reddy,KRajender;Reese,PeterP;Goldberg,DavidS
最近的数据表明，从丙型肝炎病毒（HCV）感染的供体移植肾脏每年可以增加500- 1，000例肾脏移植（KT），具有持久的治愈率和良好的1年肾功能。然而，关于急性供体源性HCV风险的数据有限，阻碍了我们告知患者和提供者的能力。我们试图检查一项试验的数据，该试验将HCV感染供体的肾脏移植给HCV阴性患者（THINKER，NCT#02743897），以确定这些受体与来自HCV阴性供体的肾的对照受体相比是否具有更大的早期丙氨酸氨基转移酶（ALT）升高的可能性。并随机选择了40名HCV阴性对照者，他们在同一时期（6/1/2016-5/23/2018）在同一中心接受了来自HCV阴性供体的KT。THINKER排除标准是“持续升高的肝转氨酶”，我们也要求对照药物用于本研究。ALT是识别肝损伤的最特异性试验，是肝损伤的指标。2主要结局是
Recent data demonstrate that transplanting kidneys from hepatitis C virus (HCV)-infected donors could increase the number of kidney transplants (KT) by 500-1,000 per year with durable cure rates and excellent 1-year renal function. 1 However, data on the risks of acute donor-derived HCV are limited, hampering our ability to inform patients and providers. We sought to examine data from a trial of transplanting HCV-negative patients with kidneys from HCV-infected donors (THINKER, NCT# 02743897) to determine whether these recipients had a greater likelihood of having early alanine aminotransferase (ALT) elevations versus comparator recipients of kidneys from HCV-negative donors.We reviewed data from the first 40 THINKER recipients transplanted at the University of Pennsylvania, and randomly selected 40 HCV-negative comparators who received a KT from an HCV-negative donor at the same center during the same period (6/1/2016-5/23/2018). A THINKER exclusion criterion was,“persistently elevated liver transaminases,” which we also required of comparators for this study. ALT, the most specific test to identify hepatic injury, was the measure of hepatic injury. 2 The primary outcome was