EXCRETION, DECONJUGATION, AND ABSORPTION OF BILE-ACIDS AFTER COLECTOMY FOR ULCERATIVE-COLITIS - COMPARATIVE-STUDIES IN PATIENTS WITH CONVENTIONAL ILEOSTOMY AND PATIENTS WITH KOCK RESERVOIR
EXCRETION, DECONJUGATION, AND ABSORPTION OF BILE-ACIDS AFTER COLECTOMY FOR ULCERATIVE-COLITIS - COMPARATIVE-STUDIES IN PATIENTS WITH CONVENTIONAL ILEOSTOMY AND PATIENTS WITH KOCK RESERVOIR
复制标题
DOI：
10.3109/00365528608996434
复制
发表时间：
1986-01-01
影响因子：
1.9
通讯作者：
JARNUM, S
中科院分区：
文献类型：
--
作者：
HYLANDER, E;LADEFOGED, K;JARNUM, S
对26例可控性回肠造口术（Kock's贮血器）和32例常规回肠造口术患者的胆汁酸代谢进行了研究。所有患者均因溃疡性结肠炎接受结肠切除术。在可控回肠造口术患者中，14 C-甘氨胆酸呼气试验显示肺14 CO2排泄增加作为胆汁酸异常细菌去结合的证据，粪便14 C排泄增加作为胆汁酸吸收不良的证据。粪便胆汁酸排泄（化学测定）和胆汁酸合成（推断）仅中度增加（中位数，1.8 mmol/天）。胆汁酸代谢的分布与32例常规回肠造口术患者相似，但粪便14 C较高时更明显。一个显着的差异是，没有异常的细菌解偶联发生在传统回肠造口术的患者，因为他们的肺14 CO2排泄低于正常。两组的粪便质量几乎相同，中位数分别为665和663 g/天。两组大部分动物的粪便脂肪排泄正常。因此，与传统回肠造口术的患者相比，可控回肠造口术的患者胆汁酸代谢略微受到干扰。两组中导致的吸收不良均为中度。
Bile acid metabolism was studied in 26 patients with a continent ileostomy (Kock''s reservoir) and 32 patients with conventional ileostomy. All had been colectomized for ulcerative colitis. In patients with a continent ileostomy the 14C-glycocholic acid breath test showed increased pulmonary 14CO2 excretion as evidence of abnormal bacterial deconjugation of bile acids and increased faecal 14C excretion as evidence of bile acid malabsorption. Faecal bile acid excretion, determined chemically, and, by inference, bile acid synthesis were only moderately increased (median, 1.8 mmol/day). The distribution of bile acid metabolism was similar to that found in 32 patients with conventional ileostomy but more pronounced with higher faecal 14C. A significant difference was that no abnormal bacterial deconjugation took place in patients with conventional ileostomy, since their pulmonary 14CO2 excretion was subnormal. Stool mass was almost identical in the two groups, with median values of 665 and 663 g/day, respectively. Faecal fat excretion was normal in most in both groups. Thus bile acid metabolism is slightly more disturbed in patients with a continent ileostomy than in patients with conventional ileostomy. The resulting malabsorption was modest in both groups.