βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function.
βlinc1 encodes a long noncoding RNA that regulates islet β-cell formation and function.
复制标题
DOI：
10.1101/gad.273821.115
复制
发表时间：
2016-03-01
影响因子：
10.5
通讯作者：
Sussel L
中科院分区：
文献类型：
--
作者：
Arnes L;Akerman I;Balderes DA;Ferrer J;Sussel L
在阿内斯等人的这项研究中，作者提供了一个新的见解，在胰腺发育和糖尿病的发展中的作用，长的非编码RNA。他们证明β linc 1通过协调调节许多胰岛特异性转录因子对胰岛素产生细胞的特化和功能是必需的，β linc 1的缺失导致成人胰岛发育缺陷和葡萄糖稳态破坏。胰腺β细胞负责维持葡萄糖稳态;它们的缺失或功能障碍导致糖尿病。虽然有证据表明，长链非编码RNA（lncRNA）在发育和疾病中发挥重要作用，但在胰腺发育的背景下，没有一个在体内进行过研究。在这项研究中，我们证明了β linc 1（β细胞长基因间非编码RNA 1），一种保守的lncRNA，通过协调调节位于β linc 1基因组附近的许多胰岛特异性转录因子，对胰岛素分泌β细胞的特异性和功能是必需的。此外，β linc 1的缺失导致成年小鼠胰岛发育缺陷和葡萄糖稳态破坏。
In this study from Arnes et al., the authors provide novel insight into the role of a long noncoding RNA in pancreas development and development of diabetes. They demonstrate that βlinc1 is necessary for the specification and function of insulin-producing cells through the coordinated regulation of a number of islet-specific transcription factors, and deletion of βlinc1 results in defective islet development and disruption of glucose homeostasis in the adult. Pancreatic β cells are responsible for maintaining glucose homeostasis; their absence or malfunction results in diabetes mellitus. Although there is evidence that long noncoding RNAs (lncRNAs) play important roles in development and disease, none have been investigated in vivo in the context of pancreas development. In this study, we demonstrate that βlinc1 (β-cell long intergenic noncoding RNA 1), a conserved lncRNA, is necessary for the specification and function of insulin-producing β cells through the coordinated regulation of a number of islet-specific transcription factors located in the genomic vicinity of βlinc1. Furthermore, deletion of βlinc1 results in defective islet development and disruption of glucose homeostasis in adult mice.