Adenocarcinoma in Ectopic Prostatic Tissue at Dome of Bladder A Case Report of a Patient With Urothelial Carcinoma of the Bladder and Adenocarcinoma of the Prostate
Adenocarcinoma in Ectopic Prostatic Tissue at Dome of Bladder A Case Report of a Patient With Urothelial Carcinoma of the Bladder and Adenocarcinoma of the Prostate
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DOI：
10.1043/2009-0338-cr.1
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发表时间：
2010-09-01
影响因子：
4.6
通讯作者：
Ro, Jae Y.
中科院分区：
文献类型：
--
作者：
Gardner, Jerad M.;Khurana, Hema;Ro, Jae Y.
我们报告一例异位前列腺组织与相关的前列腺腺癌发生在圆顶的膀胱。一位62岁男性因泌尿道感染后出现持续性镜下血尿4个月。其他主诉包括尿频，但无排尿困难或肉眼血尿。直肠指检显示前列腺光滑，大小正常。膀胱镜检查发现一个无蒂病变的前膀胱颈和多个较小的乳头状病变整个膀胱。在诊断为肌层浸润性移行细胞癌3级的经尿道膀胱肿瘤切除术后，进行了根治性膀胱切除术。移行细胞癌的诊断得到证实，但除此之外，一个不同的病变也偶然发现在圆顶的膀胱。该偶然病变显示前列腺腺癌由膀胱粘膜下层内的异位前列腺组织引起。前列腺也显示前列腺腺癌，但这是极轻微的，低级别的，并局限于前列腺，因此认为不太可能转移到膀胱顶。发生于异位前列腺组织的腺癌是一种罕见的发现，据我们所知，只有1例先前已被描述，发生在邻近前列腺的软组织。我们报告第一例腺癌发生在异位前列腺组织膀胱内。(Arch Pathol Lab Med.2010;134：1271-1275）
We report a case of ectopic prostate tissue with an associated prostatic adenocarcinoma occurring in the dome of the urinary bladder. A 62-year-old man presented with a 4-month history of persistent microscopic hematuria following a urinary tract infection. Other complaints included frequent urination, but there was neither dysuria nor gross hematuria. Digital rectal examination revealed a smooth prostate of normal size. Cystoscopic examination revealed a sessile lesion of the anterior bladder neck and multiple smaller papillary lesions throughout the bladder. Following a transurethral resection of the bladder tumor with a diagnosis of muscle-invasive transitional cell carcinoma grade 3, a radical cystoprostatectomy was performed. The diagnosis of transitional cell carcinoma was confirmed, but in addition, a different lesion was also incidentally found in the dome of the bladder. This incidental lesion showed a prostatic adenocarcinoma arising from ectopic prostatic tissue within the bladder submucosa. The prostate also showed prostatic adenocarcinoma, but this was minimal, low grade, and confined to the prostate gland, and thus it was felt to be unlikely to have metastasized to the bladder dome. Adenocarcinoma arising in ectopic prostatic tissue is a rare finding and to our knowledge only 1 case has been previously described, occurring in the soft tissue adjacent to the prostate. We report the first case of adenocarcinoma arising in ectopic prostatic tissue within the bladder. (Arch Pathol Lab Med. 2010;134:1271-1275)