THE COMPOSITIONAL PROPERTIES OF HUMAN GENES
THE COMPOSITIONAL PROPERTIES OF HUMAN GENES
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DOI：
10.1007/bf02102651
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发表时间：
1991-06-01
影响因子：
3.9
通讯作者：
BERNARDI, G
中科院分区：
文献类型：
--
作者：
AISSANI, B;DONOFRIO, G;BERNARDI, G
目前的工作代表了第一次尝试更详细地研究先前提出的基因组中的组成相关性，基于一个身体的额外的数据有关的基因定位，以及从基因库中提取的扩展侧翼序列。 我们已经研究了（1）人类基因外显子的GC水平与（2）与所考虑的基因相关的基因间序列或内含子的GC水平之间存在的相关性。 在这两种情况下，线性关系的斜率接近1。线性关系的相似性表明，在基因间序列和内含子位于相同的isochore相似的GC水平。 此外，基因间序列和内含子显示GC水平比相应的外显子低5-10%。 上述研究结果大大加强了先前得出的结论，即来自人类基因组相同等位基因的编码和非编码序列（基因间和基因内）在组成上是相关的。 此外，我们发现GC水平之间的线性相关性的密码子位置和基因间序列或内含子与相应的基因，以及之间的GC水平的密码子位置的基因。
The present work represents the first attempt to study in greater detail previously proposed compositional correlations in genomes, based on a body of additional data relating to gene localizations as well as to extended flanking sequences extracted from gene banks. We have investigated the correlations that exist between (1) the GC levels of exons of human genes, and (2) the GC levels of either intergenic sequences or introns associated with the genes under consideration. In both cases, linear relationships with slopes close to unity were found. The similarity of the linear relationships indicates similar GC levels in intergenic sequences and introns located in the same isochores. Moreover, both intergenic sequences and introns showed GC levels 5-10% lower than the corresponding exons. The above findings considerably strengthen the previously drawn conclusion that coding and noncoding sequences (both inter- and intragenic) from the same isochores of the human genome are compositionally correlated. In addition, we find linear correlations between the GC levels of codon positions and of the intergenic sequences or introns associated with the corresponding genes, as well as among the GC levels of codon positions of genes.