Household exposure to passive cigarette smoking and serum micronutrient concentrations.
Household exposure to passive cigarette smoking and serum micronutrient concentrations.
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DOI：
10.1093/ajcn/72.6.1576
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发表时间：
2000-12
期刊：
影响因子：
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通讯作者：
A. Alberg;Joyce C Chen;Hongxin Zhao;S. Hoffman;G. Comstock;K. J. Helzlsouer
中科院分区：
文献类型：
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作者：
A. Alberg;Joyce C Chen;Hongxin Zhao;S. Hoffman;G. Comstock;K. J. Helzlsouer
背景被动吸烟与不良健康结果之间的关系引起了争议。在某种程度上，这可能是因为被动吸烟者的饮食与主动吸烟者的饮食一样，与不接触香烟烟雾的人不同，特别是在抗氧化剂方面。目的：评估家庭被动吸烟暴露与血清视黄醇、生育酚和类胡萝卜素浓度之间的关系。设计：在马里兰州华盛顿县进行了一项横断面研究，比较1975年县居民私人普查中记录的家庭被动吸烟暴露与1974年收集的血清微量营养素浓度。在1986年至1998年进行的巢式病例对照研究中，对1590名对照受试者进行了比较。结果：在目前不吸烟的人群中，与吸烟者生活在一起的人群血清总类胡萝卜素、α-胡萝卜素、β-胡萝卜素和隐黄质浓度往往低于生活在不吸烟家庭的人群。几乎没有证据表明被动吸烟与血清中叶黄素和玉米黄质、番茄红素、视黄醇、α-生育酚或γ-生育酚浓度降低有关。结论：在非吸烟者中，被动吸烟倾向于与较低的血清类胡萝卜素浓度相关，这些类胡萝卜素与主动吸烟最密切相关（总类胡萝卜素、α-胡萝卜素、β-胡萝卜素和隐黄质）。被动吸烟与主动吸烟之间的关联性较弱。主动吸烟和被动吸烟之间的关联一致性表明，被动吸烟可能导致某些微量营养素的循环浓度降低。
BACKGROUND The associations observed between passive smoking and adverse health outcomes have generated controversy. In part, this could be because the diets of passive smokers, like those of active smokers, differ from those of persons who are not exposed to cigarette smoke, especially with regard to antioxidants. OBJECTIVE Our objective was to assess the relation between household exposure to passive smoking and serum concentrations of retinol, tocopherols, and carotenoids. DESIGN A cross-sectional study was conducted in Washington County, MD, to compare exposure to passive smoking at home, recorded in a private census of county residents in 1975, with micronutrient concentrations assayed in serum collected in 1974. This comparison was possible for 1590 control subjects in nested case-control studies conducted between 1986 and 1998. RESULTS Among persons who were not current smokers, those who lived with smokers tended to have lower serum total carotenoid, alpha-carotene, ss-carotene, and cryptoxanthin concentrations than did those who lived in households with no smokers. There was little evidence that exposure to passive smoking was associated with reduced serum concentrations of lutein and zeaxanthin, lycopene, retinol, alpha-tocopherol, or gamma-tocopherol. CONCLUSIONS Among nonsmokers, exposure to passive smoking tended to be associated with lower serum concentrations of the carotenoids most strongly associated with active smoking (total carotenoids, alpha-carotene, ss-carotene, and cryptoxanthin). The associations were weaker for passive smoking than for active smoking. The consistency of the associations observed for active and passive smoking indicates that exposure to passive smoking may result in decreased circulating concentrations of selected micronutrients.