The urokinase plasminogen activator and its receptor - Role in cell growth and apoptosis
The urokinase plasminogen activator and its receptor - Role in cell growth and apoptosis
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DOI：
10.1160/th04-09-0592
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发表时间：
2005-02-01
影响因子：
6.7
通讯作者：
Stoppelli, MP
中科院分区：
文献类型：
--
作者：
Alfano, D;Franco, P;Stoppelli, MP
尿型纤溶酶原激活剂或uPA通过将纤溶酶原转化为纤溶酶来控制基质降解，并且被认为是在生理和病理条件（例如癌症转移）下细胞迁移和侵袭期间纤溶酶产生的关键触发因素。uPA的蛋白水解活性负责激活或释放几种生长因子，并通过动态控制细胞-基质接触来调节细胞存活/凋亡比率。尿激酶受体（uPAR）与uPA的EGF样结构域结合，通过跨膜蛋白介导膜相关的胞外蛋白水解和信号传导，从而调节细胞迁移、粘附和细胞骨架状态。然而，最近的证据强调了一个错综复杂的关系uPA/uPAR系统连接到细胞生长和凋亡。
The urinary-type plasminogen activator, or uPA, controls matrix degradation through the conversion of plasminogen into plasmin and is regarded as the critical trigger for plasmin generation during cell migration and invasion, under physiological and pathological conditions (such as cancer metastasis). The proteolytic activity of uPA is responsible for the activation or release of several growth factors and modulates the cell survival/apoptosis ratio through the dynamic control of cell-matrix contacts. The urokinase receptor (uPAR), binding to the EGF-like domain of uPA, directs m em bran e-associated extracellular proteolysis and signals through transmembrane proteins,thus regulating cell migration, adhesion and cytoskeletal status. However, recent evidence highlights an intricate relationship linking the uPA/uPAR system to cell growth and apoptosis.