A flavonoid component from Docynia delavayi (Franch.) Schneid represses transplanted H22 hepatoma growth and exhibits low toxic effect on tumor-bearing mice.
A flavonoid component from Docynia delavayi (Franch.) Schneid represses transplanted H22 hepatoma growth and exhibits low toxic effect on tumor-bearing mice.
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DOI：
10.1016/j.fct.2012.05.039
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发表时间：
2012-09
期刊：
影响因子：
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通讯作者：
Xian-min Zhao;G. Shu;Lvyi Chen;Xue Mi;Zhinan Mei;Xukun Deng
中科院分区：
文献类型：
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作者：
Xian-min Zhao;G. Shu;Lvyi Chen;Xue Mi;Zhinan Mei;Xukun Deng
多西尼亚的果实（法语）施耐德是中国西南地区一种很受欢迎的食物。此外，它的根茎长期以来一直被当地人用作治疗肝癌的民间药物。黄菊花素是一种体外诱导癌细胞死亡的类黄酮。然而，其体内抗肿瘤活性和对荷瘤动物的毒理学作用尚不清楚。在本研究中，我们得到了四种黄酮类化合物。其中，菊花素对肿瘤细胞的杀伤作用最强。进一步研究发现，它能显著抑制移植的H22腹水肝肿瘤细胞的体内生长。此外，该化合物显示出很小的毒性作用。此外，我们发现在移植肿瘤组织中，菊花素不仅能激活caspase-3，诱导细胞凋亡，还能抑制血管内皮生长因子（VEGF）的产生，抑制血管生成。这些数据表明，菊花素在体内具有明显的抗肿瘤活性和低毒性作用。
The fruit of Docynia delavayi (Franch.) Schneid is a kind of popular food in southwestern areas of China. Additionally, its rhizome has been long used as a folk medicine in the treatment of liver cancer by local people. Chrysin is a kind of flavonoid which induces cancer cell death in vitro. However, its anti-tumor activity in vivo and toxicological effects on the tumor-bearing animals still remain poorly understood. In this study, we obtained four flavonoids from this herb. Among them, chrysin showed the strongest cytotoxic effect on an array of cultured tumor cells. Further investigations revealed that it significantly repressed transplanted H22 ascitic hepatic tumor cell growth in vivo. Moreover, this compound displayed little toxic effects. Additionally, we demonstrated that in transplanted tumor tissues, chrysin not only activated caspase-3 and induced apoptosis, but also inhibited the production of vascular endothelial growth factor (VEGF) and suppressed angiogenesis. These data showed that chrysin exhibited prominent anti-tumor activities and low toxic effects in vivo.