Genetic characterization of Y-chromosomal STRs in Hazara ethnic group of Pakistan and confirmation of DYS448 null allele
Genetic characterization of Y-chromosomal STRs in Hazara ethnic group of Pakistan and confirmation of DYS448 null allele
复制标题
巴基斯坦哈扎拉族 Y 染色体 STR 的遗传特征及 DYS448 无效等位基因的确认。
DOI：
10.1007/s00414-018-1962-x
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发表时间：
2019-05-01
影响因子：
2.1
通讯作者：
Pang, Hao
中科院分区：
文献类型：
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作者：
Adnan, Atif;Rakha, Allah;Pang, Hao
巴基斯坦有18个主要民族，哈扎拉人是其中一个独特但较小的民族，占总人口的0.090%。哈扎拉人具有典型的蒙古人面部特征，他们自称是公元世纪前25年成吉思汗军队的后裔。在这项研究中，我们基因型153无关的男性生活在奎达，俾路支省，巴基斯坦，共26（n = 153）至30（n = 47）Y染色体STR基因座。使用Powerplant Y23基因座为哈扎拉人群体开发了140种独特的单倍型。Y-STR基因座的遗传多样性范围为0.2384 ~ 0.7918，总识别力为91.5%。对哈扎拉人群体样本进行了三个额外的Y-STR（DYS 388、DYS 449和DYS 460）的分析，这将独特单倍型的数量增加到144，而巴基斯坦哈扎拉人群体中的DC增加到94.11%。有趣的是，在哈扎拉人群的25名个体中观察到DYS 448的无效等位基因。哈扎拉人与巴基斯坦其他当地人口以及邻近人口有显着差异，但与哈萨克人和蒙古人有相当大的遗传亲缘关系。
Pakistan harbors 18 major ethnic groups and Hazara is one of the distinct but smaller groups comprising 0.090% of the total population. Hazara individuals have typical Mongolian facial features and they claim to be descendants of Genghis Khan's army in the first quarter of the thirteenth century AD. In this study, we genotyped 153 unrelated males living in Quetta, Baluchistan, Pakistan, for a total of 26 (n = 153) to 30 (n = 47) Y-chromosomal STR loci. One hundred forty unique haplotypes were developed for Hazara population using the PowerPlex Y23 loci. The Y-STR locus showed a genetic diversity ranging from 0.2384 to 0.7918, and an overall discrimination capacity (DC) of 91.5%. The Hazara population samples were profiled for three additional Y-STRs (DYS388, DYS449 and DYS460), which increased the number of unique haplotypes to 144 while the DC increased to 94.11% in Hazara Population of Pakistan. Interestingly, null alleles were observed at DYS448 in 25 individuals of Hazara population. The Hazaras showed significant differences from other local populations of Pakistan as well as neighboring populations, but had considerable genetic affinities to Kazakhs and Mongols.