Ectopically-expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human gammadelta T cells to induce innate anti-tumor/virus immunity
Ectopically-expressed human tumor biomarker MutS homologue 2 is a novel endogenous ligand that is recognized by human gammadelta T cells to induce innate anti-tumor/virus immunity
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发表时间：
2012
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通讯作者：
Y. Dai;Hui Chen;C. Mo;L. Cui;Wei He
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作者：
Y. Dai;Hui Chen;C. Mo;L. Cui;Wei He
背景：hMSH 2是一种肿瘤标志物，其识别机制尚不清楚。结果：hMSH 2与Vδ2 T细胞表面的TCRγδ和NKG 2D相互作用，导致Vδ2 T细胞活化。EBV感染可上调其表达。结论：hMSH 2是TCRγδ和NKG 2D的配体。意义：γδ T细胞识别hMSH 2诱导先天性抗肿瘤/病毒免疫。
Background: Ectopically-expressed hMSH2 is tumor biomarker, however, the mechanism of its recognition is unclear. Results: hMSH2 interacted with both TCRγδ and NKG2D on Vδ2 T cells, resulting in Vδ2 T cell activation. Its expression was up-regulated by EBV infection. Conclusion: hMSH2 is a ligand for TCRγδ and NKG2D. Significance: Recognition of hMSH2 by γδ T cells induces innate anti-tumor/virus immunity.