Age-specific incidence rates of Alzheimer's disease - The Baltimore Longitudinal Study of Aging
Age-specific incidence rates of Alzheimer's disease - The Baltimore Longitudinal Study of Aging
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DOI：
10.1212/wnl.54.11.2072
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发表时间：
2000-06-13
期刊：
影响因子：
9.9
通讯作者：
Zonderman, A
中科院分区：
文献类型：
--
作者：
Kawas, C;Gray, S;Zonderman, A
目的：在巴尔的摩衰老纵向研究（BLSA）中估计阿尔茨海默病（AD）特定年龄的发病率。
背景：BLSA是一个正常受试者的志愿者队列，在国家衰老研究所老年医学研究中心进行纵向随访，每两年评估一次。
方法：研究对象为1985年1月至1998年5月期间在BLSA中接受纵向随访的1236名参与者（802名男性，434名女性）。平均随访时间为7.5年，参与者每2年接受一次身体、神经和神经心理学检查评估。作者使用《精神障碍诊断与统计手册》第三版修订版以及美国国家神经疾病和沟通障碍及中风 - 阿尔茨海默病及相关疾病协会的标准诊断痴呆和AD。
结果：作者诊断出155例痴呆病例，其中114例（74%）为AD。AD发病率随年龄增长而增加，在60 - 65岁年龄组中，男女合计每年估计为0.08%（95%置信区间为0.00 - 0.43），在85岁及以上年龄组中每年估计为6.48%（95%置信区间为5.01 - 8.38）。发病率翻倍时间估计约为4.4年，从轻度认知障碍转变为AD诊断的中位时间估计为4.4年。女性发病率高于男性以及受教育年限较少与较高发病率相关存在一种趋势；然而，这些影响并不显著。
结论：BLSA中AD的发病率与其他研究中公布的发病率一致。BLSA中纵向随访的受试者为前瞻性研究AD的病因提供了独特的机会。
Objective: To estimate age-specific incidence rates of AD in the Baltimore Longitudinal Study of Aging (BLSA). Background: The BLSA is a volunteer cohort of normal subjects followed longitudinally with biennial evaluations at the Gerontology Research Center of the National Institute on Aging. Methods: Subjects are 1236 participants (802 men, 434 women) in the BLSA with longitudinal follow-up between January 1985 and May 1998. The average length of follow-up was 7.5 years, with participants evaluated every 2 years by physical, neurologic, and neuropsychological examinations. Using Diagnostic and Statistical Manual of Mental Disorders, 3rd ed,, revised and National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria, the authors diagnosed dementia and AD. Results: The authors diagnosed 155 cases of dementia, of which 114 (74%) were AD. Incidence rates of AD increased with age from an estimated 0.08% per year (95% CI 0.00 to 0.43) in the 60 to 65 age group to an estimated 6.48% per year (95% CI 5.01 to 8.38) in the 85+ age group for men and women combined. The doubling time of incidence rates was estimated to be approximately 4.4 years and the median time of conversion from mild cognitive impairment to diagnosis of AD was estimated to be 4.4 years. There was a trend for women to have higher incidence rates than men and for fewer years of education to be associated with higher incidence rates; however, these effects mere not significant. Conclusion: Incidence rates for AD in the BLSA are consistent with published rates in other studies. The longitudinally followed subjects of the BLSA offer a unique opportunity to prospectively investigate the antecedents of AD.