The role of interleukin-6 in stress-induced hyperthermia and emotional behaviour in mice
The role of interleukin-6 in stress-induced hyperthermia and emotional behaviour in mice
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DOI：
10.1016/s0166-4328(03)00059-7
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发表时间：
2003-09-15
影响因子：
2.7
通讯作者：
Schwaninger, M
中科院分区：
文献类型：
--
作者：
Butterweck, V;Prinz, S;Schwaninger, M
心理压力会影响行为以及自主神经功能，如体温。在应激过程中诱导体温过高的机制尚不清楚。最近的一个假说认为，白细胞介素-6（IL-6），一种内源性热原，在应激过程中升高体温。为了研究IL-6在应激过程中的作用，我们通过定量PCR测定了小鼠暴露于旷场应激后60分钟各种组织中IL-6的mRNA水平。IL-6 mRNA在下丘脑中升高3倍，在垂体中升高2倍。然而，在暴露于60分钟的旷场应激后，野生型对照动物（35.2 +/- 0.6-37.3 +/- 0.5 ℃）和IL-6缺陷动物（34.8 +/- 0.4-37.0 +/- 0.3 ℃）的体温升高之间没有差异。与体温相反，野生型对照组和IL-6缺陷小鼠的情绪行为不同。IL-6缺乏的动物表现出较高的运动活动，在一个开放的举行和较低水平的探索开放臂的高架十字迷宫比对照组动物。这些数据表明，IL-6在情绪控制中起重要作用，但在心理应激后的体温调节中不起作用。(C)2003 Elsevier Science B. V.保留所有权利。
Psychological stress influences behaviour as well as autonomic functions such as body temperature. The mechanism that induces hyperthermia during stress is unknown. A recent hypothesis suggests that interleukin-6 (IL-6), an endogenous pyrogen, elevates body temperature during stress. To investigate the role of IL-6 during stress, we measured mRNA levels of IL-6 by quantitative PCR in various tissues 60 min after exposure of mice to open field stress. IL-6 mRNA was elevated in the hypothalamus three-fold and in the pituitary two-fold. However, there was no difference between the increase in body temperature after exposure to 60 min open field stress in wild-type controls (35.2 +/- 0.6-37.3 +/- 0.5 degreesC) and IL-6-deficient animals (34.8 +/- 0.4-37.0 +/- 0.3 degreesC). In contrast to body temperature, emotional behaviour differed between wild-type controls and IL-6-deficient mice. IL-6-deficient animals showed higher locomotor activity in an open Held and lower levels of exploration of the open arms of the elevated plus maze than control animals. These data suggest that IL-6 plays an important role in the control of emotionality, but not in the regulation of body temperature after psychological stress. (C) 2003 Elsevier Science B.V. All rights reserved.