Antioxidant activity of stilbene glycoside from Polygonum multiflorum Thunb in vivo
Antioxidant activity of stilbene glycoside from Polygonum multiflorum Thunb in vivo
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DOI：
10.1016/j.foodchem.2007.03.022
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发表时间：
2007-01-01
期刊：
影响因子：
8.8
通讯作者：
Ho, Chi-Tang
中科院分区：
文献类型：
--
作者：
Lv, LiShuang;Gu, XiaoHong;Ho, Chi-Tang
从何首乌根的乙醇提取物中分离得到二苯乙烯苷类化合物。得到两个样品：通过大孔树脂分离的级分和2，3，5，4 '-四羟基二苯乙烯2-O-β-吡喃葡萄糖苷的纯晶体。采用大鼠体内抗氧化试验评价两种样品的抗氧化活性。二苯乙烯苷能提高D-半乳糖致衰老大鼠血清和器官（肝、心、脑）中超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性，降低2-硫代巴比妥酸反应物质（TBARS）的含量。结论：何首乌二苯乙烯苷具有较强的体内抗氧化活性。(c)2007爱思唯尔有限公司版权所有。
Stilbene glycosides were isolated from the ethanol extract of the roots of Polygonum multiflorum Thunb. Two samples were obtained; a fraction separated by macroporous resin and pure crystals of 2,3,5,4 '-tetrahydroxystilbene 2-O-beta-glucopyrano side. The antioxidant activities of these two samples were evaluated using antioxidant tests of rats in vivo. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of the serum and the organs (liver, heart and brain of rats) of D-galactose induced senile rats which were fed with stilbene glycoside, were increased; however, the content of 2-thiobarbituric acid-reactive substances (TBARS) was decreased. It is concluded that the stilbene glycoside from Polygonum multiflorum Thunb possesses high in vivo antioxidant activity. (c) 2007 Elsevier Ltd. All rights reserved.