Increased Phagocytosis of Platelets from Patients with Secondary Dengue Virus Infection by Human Macrophages
Increased Phagocytosis of Platelets from Patients with Secondary Dengue Virus Infection by Human Macrophages
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DOI：
10.4269/ajtmh.2009.80.841
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发表时间：
2009-05-01
影响因子：
3.3
通讯作者：
Oishi, Kazunori
中科院分区：
文献类型：
--
作者：
Honda, Shoko;Saito, Mariko;Oishi, Kazunori
应用流式细胞术检测了36例登革病毒（DV）继发感染患者THP-1细胞吞噬血小板百分率与外周血血小板计数及血小板相关IgG（PAIgG）的关系。与健康志愿者相比，这些患者在急性期的吞噬百分比和PAIgG水平显着增加。在急性期发现的增加的吞噬百分比和PAIgG在恢复期显著降低。急性期血小板计数与吞噬百分率（P = 0.011）及PAIgG水平（P = 0.041）呈负相关。然而，没有发现吞噬百分比和PAIgG水平之间的相关性。我们目前的数据表明，加速血小板吞噬发生在急性期的继发性DV感染，这是血小板减少症在这种疾病的机制之一。
The relationship between the percent phagocytosis of platelets by differentiated THP-1 cells was examined using flowcytometry and the peripheral platelet counts as well as platelet-associated IgG (PAIgG) in 36 patients with secondary dengue Virus (DV) infections. The percent phagocytosis and the levels of PAIgG were significantly increased in these patients during the acute phase compared with the healthy volunteers. The increased percent phagocytosis and PAIgG found during the acute phase significantly decreased during the convalescent phase. An inverse correlation between platelet count and the pet-cent phagocytosis (P = 0.011) and the levels of PAIgG (P = 0.041) was found among these patients during the acute phase. No correlation was found, however, between the percent phagocytosis and the levels of PAIgG. Our present data suggest that accelerated platelet phagocytosis occurs during the acute phase of secondary DV infections, and it is one of the mechanisms of thrombocytopenia in this disease.