Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females
Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females
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DOI：
10.1016/j.joca.2003.08.010
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发表时间：
2004-02-01
影响因子：
7
通讯作者：
Cicuttini, FM
中科院分区：
文献类型：
--
作者：
Jones, G;Ding, CH;Cicuttini, FM
目的：描述早期放射学膝关节骨关节炎 (ROA)、膝关节软骨体积和胫骨表面积之间的关联。方法：对 372 名男性和女性受试者（平均年龄 45 岁，范围 26-61）进行横断面方便样本。通过使用 T1 加权脂肪饱和 MRI 处理矢状面获取的图像，确定髌骨、胫骨内侧和胫骨外侧室的关节软骨体积、骨面积和体积。 ROA 通过站立半屈 X 光片和 OARSI 图集评估关节间隙狭窄和骨赘增生。 X 光片和 MRI 均在右膝进行，并由不同的观察者读取。结果：17% 的受试者存在 ROA（主要为 1 级），其中内侧关节间隙狭窄最常见（14%），其次是内侧骨赘（6%）。一级内侧关节间隙狭窄与膝关节内内侧和外侧胫骨和髌骨部位的软骨体积大幅减少相关（调整后的平均差 11-13%，所有 P
Objective: To describe the association between early radiographic osteoarthritis of the knee (ROA), knee cartilage volume and tibial bone surface area.Methods: Cross-sectional convenience sample of 372 male and female subjects (mean age 45 years, range 26-61). Articular cartilage volume, bone area and volume were determined at the patella, medial tibial and lateral tibial compartments by processing images acquired in the sagittal plane using T1-weighted fat saturation MRI. ROA was assessed with a standing semiflexed radiograph and the OARSI atlas for joint space narrowing and osteophytosis. Both radiographs and MRIs were performed in the right knee and read by different observers.Results: ROA (predominantly grade 1) was present in 17% of subjects of which medial joint space narrowing was most common (14%) followed by medial osteophytes (6%). Grade one medial joint space narrowing was associated with substantial reductions in cartilage volume at both the medial and lateral tibial and patellar sites within the knee (adjusted mean difference 11-13%, all P