High-intensity static magnetic fields modulate skin microcirculation and temperature in vivo.
High-intensity static magnetic fields modulate skin microcirculation and temperature in vivo.
复制标题
高强度静磁场调节皮肤微循环和体内温度。
作者：
Shigeru Ichioka;Masayuki Minegishi;M. Iwasaka;Masahiro Shibata;Takashi Nakatsuka;Kiyonori Harii;Akira Kamiya;S. Ueno
我们研究了高达8 T的静磁场对麻醉大鼠皮肤血流量和体温的急性影响。这些变量被测量之前，期间，和之后暴露于磁场中的超导磁体与水平孔。将背部皮肤横向切开1 cm以形成皮下袋。将激光多普勒流量计和热敏电阻的探头插入囊袋中并定位在背中部以测量皮肤血流量和温度。将另一热敏电阻探头放入直肠以监测直肠温度。在磁体外进行基线测量后，将大鼠插入孔中20分钟，使得中背精确地定位在中心，其中磁场几乎均匀。然后在孔外记录暴露后变化20 min。假暴露的动物被提交到完全相同的条件下，除了超导磁体没有通电。在磁场暴露期间，皮肤血流量和温度显著降低，并在将动物从磁体上移除后恢复。当动物处于磁体中时，直肠温度呈下降趋势。本研究中的微循环和热反应是一致的，并同意一些基于数学模拟和模型实验的预测。
We investigated the acute effect of static magnetic fields of up to 8 T on skin blood flow and body temperature in anesthetized rats. These variables were measured prior to, during, and following exposure to a magnetic field in a superconducting magnet with a horizontal bore. The dorsal skin was transversely incised for 1 cm to make a subcutaneous pocket. Probes of a laser Doppler flowmeter and a thermistor were inserted into the pocket and positioned at mid-dorsum to measure skin blood flow and temperature. Another thermistor probe was put into the rectum to monitor rectal temperature. After baseline measurement outside the magnet, the rat was inserted into the bore for 20 min so that mid-dorsum was exactly positioned at the center, where the magnetic field was nearly homogeneous. Post-exposure changes were then recorded for 20 min outside the bore. Sham-exposed animals were submitted to exactly the same conditions, except that the superconducting magnet was not energized. Skin blood flow and temperature decreased significantly during magnetic field exposure and recovered after removal of the animal from the magnet. The rectal temperature showed a tendency to decrease while the animal was in the magnet. The microcirculatory and thermal reactions in the present study were consistent and agreed with some of the predictions based on mathematical simulations and model experiments.