Osteopontin deficiency enhances parathyroid hormone/ parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology.
Osteopontin deficiency enhances parathyroid hormone/ parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology.
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DOI：
10.1016/j.tice.2011.02.003
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发表时间：
2011-06
期刊：
影响因子：
2.6
通讯作者：
Noda, Masaki
中科院分区：
文献类型：
--
作者：
Morishita, Maki;Ono, Noriaki;Miyai, Kentano;Nakagawa, Tomomi;Hanyu, Ryo;Nagao, Masashi;Kamolratanakul, Paksinee;Notomi, Takuya;Rittling, Susan R.;Denhardt, David T.;Kronenberg, Henry M.;Ezura, Yoichi;Hayata, Tadayoshi;Nakamoto, Tetsuya;Noda, Masaki
甲状旁腺激素/甲状旁腺激素相关蛋白受体（PPR）信号被认为与牙齿发育有关。在骨中，细胞外基质蛋白骨桥蛋白（OPN）是骨形成过程中PPR信号的负调节因子。然而，OPN在牙齿发育过程中对PPR作用的调节作用尚不清楚。因此，我们检查了双突变小鼠的牙齿。在OPN存在或不存在的情况下，组成型活性PPR在成牙细胞和成骨细胞（caPPR-tg）中特异性表达。x线分析显示，与野生型相比，caPPR-tg小鼠的第三磨牙（M3）和门牙长度减少，并且在没有OPN （caPPR-tg OPN- ko）的情况下，这种减少的磨牙和门牙长度进一步增强。在门牙的组织学方面，caPPR-tg诱导成牙细胞形状的高细胞性和不规则性，并且由于OPN的缺失而增强。这些形态学观察表明，OPN调节参与牙齿形成的PPR信号。
Parathyroid hormone/parathyroid hormone-related protein receptor (PPR) signaling is known to be involved in tooth development. In bone, extracellular matrix protein osteopontin (OPN) is a negative regulator of PPR signaling in bone formation. However, the role of OPN in modulation of PPR action in tooth development is not understood. Therefore, we examined the tooth in double mutant mice. Constitutively active PPR was expressed specifically in the odontoblasts and osteoblasts (caPPR-tg) in the presence or absence of OPN. Radiographic analysis indicated that the length of the third molar (M3) and the incisor was decreased in the caPPR-tg mice compared to wild type, and such reduction in molar and incisor length was further enhanced in the absence of OPN (caPPR-tg OPN-KO). With respect to histology of incisors, caPPR-tg induced high cellularity and irregularity in odontoblastic shape and this was enhanced by the absence of OPN. These morphological observations suggest that OPN modulates PPR signaling that are involved in tooth formation.
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DOI：
10.1084/jem.193.3.399
发表时间：
2001-02-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ishijima M;Rittling SR;Yamashita T;Tsuji K;Kurosawa H;Nifuji A;Denhardt DT;Noda M
通讯作者：
Noda M
影响因子：
46.9
作者：
Adams, Gregor B.;Martin, Roderick P.;Scadden, David T.
通讯作者：
Scadden, David T.
影响因子：
4.1
作者：
Kitahara, Y;Suda, N;Takano, Y
通讯作者：
Takano, Y
影响因子：
2.6
作者：
Calvi, LM;Shin, HI;Schipani, E
通讯作者：
Schipani, E
影响因子：
4.8
作者：
Ono, Noriaki;Nakashima, Kazuhisa;Noda, Masaki
通讯作者：
Noda, Masaki