Congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker disease): ten-year experience at Dallas children's medical center
Congenital self-healing reticulohistiocytosis (Hashimoto-Pritzker disease): ten-year experience at Dallas children's medical center
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DOI：
10.1016/j.jaad.2006.09.001
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发表时间：
2007-02-01
影响因子：
13.8
通讯作者：
Hoang, Mai P.
中科院分区：
文献类型：
--
作者：
Kapur, Payal;Erickson, Christof;Hoang, Mai P.
先天性自愈性网状组织细胞增生症（CSHR）的真实的发病率可能被低估，因为它的自发解决率高，缺乏临床识别。目前，除了临床，没有其他标准可以可靠地区分CSHR和播散性朗格汉斯细胞组织细胞增生症（LCH）的皮肤受累。在这项研究中，我们研究的作用，E-钙粘蛋白，Ki-67，磷酸化组蛋白H3（PHH 3）的免疫组化染色区分CSHR从播散性LCH。我们发现两组间的组织学特征和E-cadherin、Ki-67和PHH 3的表达无显著差异，从而支持了CSHR和LCH代表同一疾病谱的不同末端的理论。
The real incidence of congenital self-healing reticulohistiocytosis (CSHR) may be underreported because of its high rate of spontaneous resolution and lack of clinical recognition. Currently, there are no criteria other than clinical that can reliably distinguish CSHR from cutaneous involvement by disseminated Langerhans cell histiocytosis (LCH). In this study we investigate the role of E-cadherin, Ki-67, and phosphorylated histone H3 (PHH3) immunohistochemical stains in distinguishing CSHR from disseminated LCH. We found that no significant difference was seen in the histologic features and the expression of E-cadherin, Ki-67, and PHH3 between the two groups; thus supporting the theory that CSHR and LCH represent different ends of a spectrum of the same condition.