Engineering stability, longevity, and miscibility of microtubule-based active fluids
Engineering stability, longevity, and miscibility of microtubule-based active fluids
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DOI：
10.1039/d1sm01289d
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发表时间：
2022-01-18
期刊：
影响因子：
3.4
通讯作者：
Dogic，Zvonimir
中科院分区：
文献类型：
--
作者：
Chandrakar，Pooja;Berezney，John;Dogic，Zvonimir
基于微管的活性物质提供了对运动相互作用成分的自组织的洞察。我们描述了基于微管的 3D 活性各向同性流体的几种配方。这些流体的动力学由三种类型的驱动蛋白马达提供动力：处理马达、非处理马达和永久连接到微管主干的马达。另一种修饰使用特定的微管交联剂来诱导束形成，而不是非特定的聚合物消耗剂。与已经建立的系统相比，每种配方都表现出独特的特性。这些进展揭示了基于微管的活性流体的时间稳定性，同时扩大了其范围和适用性。
Microtubule-based active matter provides insight into the self-organization of motile interacting constituents. We describe several formulations of microtubule-based 3D active isotropic fluids. Dynamics of these fluids is powered by three types of kinesin motors: a processive motor, a non-processive motor, and a motor which is permanently linked to a microtubule backbone. Another modification uses a specific microtubule crosslinker to induce bundle formation instead of a non-specific polymer depletant. In comparison to the already established system, each formulation exhibits distinct properties. These developments reveal the temporal stability of microtubule-based active fluids while extending their reach and the applicability.