Disproportionate elevation of N-terminal pro-brain natriuretic peptide in scleroderma-related pulmonary hypertension
Disproportionate elevation of N-terminal pro-brain natriuretic peptide in scleroderma-related pulmonary hypertension
复制标题
DOI：
10.1183/09031936.00074309
复制
发表时间：
2010-01-01
影响因子：
24.3
通讯作者：
Hassoun, P. M.
中科院分区：
文献类型：
--
作者：
Mathai, S. C.;Bueso, M.;Hassoun, P. M.
N-末端脑钠肽前体（NT-proBNP）是一种神经激素激活的标志物，可用于各种形式的肺动脉高压（PAH）的诊断和预后。我们试图在与系统性硬化症（PAH-SSc）和特发性PAH（IPAH）患者相关的PAH队列中检测和比较NT-proBNP水平，比较从PAH-SSc和IPAH患者中收集的NT-proBNP水平，并与血流动力学变量相关。建立考克斯比例风险模型以评估NT-proBNP的预测价值。纳入98例患者（55例PAH-SSc，43例IPAH）。血流动力学相似，但PAH-SSc的平均肺动脉压较低。PAH-SSc患者的NT-proBNP水平显著较高（3，419 +/-3，784 vs 1，393 +/-1，633 pg.mL（-1）p
N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker of neurohormonal activation that is useful in the diagnosis and prognosis of various forms of pulmonary arterial hypertension (PAH). We sought to characterise and compare NT-proBNP in a cohort of PAH related to systemic sclerosis (PAH-SSc) and idiopathic PAH (IPAH) patients.NT-proBNP levels, collected from PAH-SSc and IPAH patients followed prospectively, were compared and correlated with haemodynamic variables. Cox proportional hazard models were created to assess the predictive value of NT-proBNP.98 patients (55 PAH-SSc, 43 IPAH) were included. Haemodynamics were similar, except for lower mean pulmonary arterial pressure in PAH-SSc. NT-proBNP levels were significantly higher in PAH-SSc (3,419 +/- 3,784 versus 1,393 +/- 1,633 pg.mL(-1) p