LYSOSOMAL ENZYME INHIBITION BY TRYPAN BLUE - A THEORY OF TERATOGENESIS
LYSOSOMAL ENZYME INHIBITION BY TRYPAN BLUE - A THEORY OF TERATOGENESIS
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DOI：
10.1126/science.157.3793.1180
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发表时间：
1967-01-01
期刊：
影响因子：
56.9
通讯作者：
GRIFFITHS, A
中科院分区：
文献类型：
--
作者：
BECK, F;LLOYD, JB;GRIFFITHS, A
A mechanism of mammalian teratogenesis involving inhibition of embryotrophic nutrition is suggested and exemplified by the action of trypan blue on pregnant rats. There is evidence for the localization of trypan blue in hetero-lysosomes of the epithelium of the visceral yolk sac, and experiments indicate that the dye is an inhibitor of a selection of hydrolytic enzymes present in lysosomal fractions from homogenates of rat visceral yolk sac. It seems likely that trypan blue inhibits the in-tracellular digestion of embryotroph by the visceral yolk-sac epithelium; the conceptus may therefore be deprived of essential nutrients at critical stages of development.
