Left atrial function assessed by speckle tracking echocardiography in anthracycline-induced cardiotoxicity: a case report.
Left atrial function assessed by speckle tracking echocardiography in anthracycline-induced cardiotoxicity: a case report.
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DOI：
10.1093/ehjcr/ytaa355
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Tsujita K
中科院分区：
文献类型：
--
作者：
Sueta D;Usuku H;Kinoshita Y;Tsujita K
癌症化疗所致心脏毒性的发病预防和早期诊断非常重要，早期发现心功能不全并开始治疗以提高治疗效果非常重要。1例31岁女性乳腺癌患者接受了表阿霉素（400 mg/m2）和环磷酰胺化疗，随后接受多西他赛化疗。化疗开始两个月后，超声心动图测定的左心室（LV）射血分数（LVEF）降至41.2%，她被诊断为癌症治疗相关心功能不全（CTRCD）。开始癌症治疗后3个月，舒张晚期二尖瓣多普勒血流（A波）的峰值速度变得不可检测。反映左房储血功能的峰值纵向应变（LS）和峰值LS率与LVEF和LV总体LS（GLS）一样逐渐下降。在开始癌症治疗7个月后，她被诊断为急性失代偿性心力衰竭。LS峰值和发作时LS峰值的变化大于LVEF和LV-GLS。这是一份病例报告，表明在检测CTRCD时，LA储库功能可能是比LVEF或LV-GLS更敏感的指标，LA增强功能可能是最早的指标。左房储库功能可能比常规左室泵功能更敏感，是判断CTRCD的最佳指标。
The onset prevention and early diagnosis in cardiotoxicity due to cancer chemotherapy are important, and it is important to detect cardiac dysfunction at an early stage and start treatment to enhance the therapeutic effect. A 31-year-old female with breast cancer received chemotherapy with epirubicin (400 mg/m2) and cyclophosphamide followed by docetaxel. Two months after the initiation of her chemotherapy, the left ventricular (LV) ejection fraction (LVEF) determined by echocardiography fell to 41.2%, and she was diagnosed with cancer therapy-related cardiac dysfunction (CTRCD). Three months after the initiation of cancer treatment, the peak velocity of late diastolic transmitral Doppler flow (A wave) became undetectable. Peak longitudinal strain (LS) and peak LS rate, which reflect left atrium (LA) reservoir function, gradually declined like the LVEF and LV-global LS (GLS). Seven months after the initiation of cancer treatment, she was diagnosed with acute decompensated heart failure. The changes in peak LS and peak LS at the onset were greater than those in LVEF and LV-GLS. This is a case report suggesting that LA reservoir function might be a more sensitive indicator than LVEF or LV-GLS in detecting CTRCD and that LA booster function might be the earliest. Left atrium reservoir function might be a more sensitive than conventional LV pump function and optimal indicator in CTRCD.
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影响因子：
6.2
作者：
Nochioka, Kotaro;Quarta, Candida Cristina;Solomon, Scott D.
通讯作者：
Solomon, Scott D.
影响因子：
2.8
作者：
Cameli, Matteo;Lisi, Matteo;Mondillo, Sergio
通讯作者：
Mondillo, Sergio
DOI：
10.1111/echo.14487
发表时间：
2019-10-01
影响因子：
1.5
作者：
Timoteo, Ana Teresa;Branco, Luisa Moura;Ferreira, Rui Cruz
通讯作者：
Ferreira, Rui Cruz
影响因子：
39.3
作者：
Zamorano, Jose Luis;Lancellotti, Patrizio;Windecker, Stephan
通讯作者：
Windecker, Stephan
DOI：
10.1161/circheartfailure.115.002763
发表时间：
2016-04
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Santos AB;Roca GQ;Claggett B;Sweitzer NK;Shah SJ;Anand IS;Fang JC;Zile MR;Pitt B;Solomon SD;Shah AM
通讯作者：
Shah AM