Spontaneous or natural killer cytotoxicity of K562 erythroleukemic cells in normal patients.
Spontaneous or natural killer cytotoxicity of K562 erythroleukemic cells in normal patients.
复制标题
正常患者中 K562 红白血病细胞的自发或自然杀伤细胞毒性。
作者：
J. Nagel;G. Collins;W. Adler
从200名正常人，年龄20至95岁，外周血单核细胞的能力进行了评估，以介导自发性或自然杀伤（NK）细胞毒性的K562红白血病细胞作为目标。4小时~（51）Cr特异性释放试验的结果表明，正常人的NK活性与年龄、性别和吸烟习惯无关。虽然个体之间差异很大，NK活性的25人重新研究后，平均20个月的时间间隔保持稳定。缺乏NK细胞溶解活性不是老年人的特征。
Peripheral blood mononuclear cells from 200 normal individuals, ages 20 to 95 years, were evaluated for their capability to mediate spontaneous or natural killer (NK) cytotoxicity using the K562 erythroleukemic cells as targets. The results of a 4-hr 51Cr specific release assay demonstrated that the NK activity of normal individuals is independent of age, sex, and smoking habits. Although varying greatly among individuals, the NK activity of 25 persons restudied after a mean 20-month interval remained stable. Deficient NK lytic activity is not characteristic of elderly individuals.