Y Chromosome Haplotypes and Prostate Cancer in Sweden
Y Chromosome Haplotypes and Prostate Cancer in Sweden
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DOI：
10.1158/1078-0432.ccr-08-0658
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发表时间：
2008-10-15
影响因子：
11.5
通讯作者：
Wiklund, Fredrik
中科院分区：
文献类型：
--
作者：
Lindstrom, Sara;Adami, Hans-Olov;Wiklund, Fredrik
目的：在日本人群中，某些Y染色体谱系被认为是易患前列腺癌的个体；然而，在其他民族中，Y染色体的重要性被很好地理解。实验设计：为了评估Y染色体对前列腺癌风险和预后的可能贡献，我们分析了来自瑞典人群的1,447例前列腺癌病例和983例对照人群中的5个二进制Y染色体标记。这五个标记加在一起，捕获了瑞典人口中Y染色体单倍组多样性的绝大多数。个体血统被测试与前列腺癌风险和癌症特异性死亡的相关性。我们在一项独立的瑞典前列腺癌病例对照研究中复制了观察到的关联。结果：一个罕见的家族(I1c)与前列腺癌风险的增加相关[优势比(OR)，2.9；95%可信区间(CI)，1.4-5.8；P=0.001]。然而，在独立的病例对照研究中，对这一谱系的验证性分析显示，与前列腺癌风险无关(OR，0.65；95%CI，0.4-1.2，P=0.17)。我们没有观察到Y染色体变异与前列腺癌特异性死亡之间的关联。结论：这项研究提供了强有力的证据，证明Y染色体在瑞典人群前列腺癌的发生或转归中起着重要作用。
Purpose: Certain Y-chromosomal lineages have been suggested to predispose individuals to prostate cancer in the Japanese population; in other ethnic groups, however, the importance of the Y chromosome is poorly understood.Experimental Design: To assess the possible Y-chromosomal contribution to prostate cancer risk and prognosis, we analyzed five binary Y-chromosomal markers in 1,447 prostate cancer cases and 983 population controls from the Swedish population. Together, these five markers capture the vast majority of chromosome Y haplogroup diversity in the Swedish population. Individual lineages were tested for association with both prostate cancer risk and cancer-specific death. We replicated observed associations in an independent Swedish prostate cancer case-control study comprising 1,452 cases and 779 controls.Results: One rare lineage (I1c) was associated with an increased risk of developing prostate cancer [odds ratio (OR), 2.9; 95% confidence interval (CI), 1.4-5.8; P = 0.001]. However, confirmatory analysis of this lineage in the independent case-control study revealed no association with prostate cancer risk (OR, 0.65; 95% CI, 0.4-1.2, P = 0.17). We observed no association between chromosome Y variation and prostate cancer-specific death.Conclusions: This study provides strong evidence against an important role of the Y chromosome in the initiation or outcome of prostate cancer in the Swedish population.