A preliminary study of skin ultrasound in diffuse cutaneous systemic sclerosis: Does skin echogenicity matter?
A preliminary study of skin ultrasound in diffuse cutaneous systemic sclerosis: Does skin echogenicity matter?
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皮肤超声在弥漫性皮肤系统性硬化症中的初步研究：皮肤回声重要吗？
DOI：
10.1371/journal.pone.0174481
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Zeng XF
中科院分区：
文献类型：
--
作者：
Liu H;Hou Y;Zhu QL;Xu D;Wang L;Li JC;Jiang YX;Wang Q;Li MT;Zhang FC;Zeng XF
目的评价皮肤超声和声辐射力脉冲（ARFI）定量在弥漫性皮肤系统性硬化症（dcSSc）中的应用价值。患者与方法28例dcSSc患者和15例年龄性别匹配的正常对照。在17个部位通过超声测量皮肤回声、厚度和ARFI定量，这些部位对应于每位参与者的改良Rodnan皮肤评分（mRSS）。与对照组相比，dcSSc患者的皮肤回声分为等回声、低回声和高回声。比较等回声、低回声、高回声和对照组的皮肤厚度、ARFI定量和mRSS。结果dcSSc患者的皮肤厚度随回声强度的变化而增加，回声强度依次为等回声、低回声和高回声。高回声组的ARFI定量显著高于等回声组（p<0.001）。高回声和/或低回声区的mRSS明显高于等回声区。对于等回声患者和健康对照者，皮肤回声或厚度没有显著差异，然而，等回声患者的ARFI定量显著高于对照者。结论皮肤超声对dcSSc皮肤受累的评估是可行的。皮肤回声与皮肤厚度、硬度和mRSS相关。与皮肤回声和厚度相比，ARFI定量可能对检测皮肤变化更敏感。
Objective To evaluate the usefulness of skin ultrasound and acoustic radiation force impulse (ARFI) quantification in diffuse cutaneous systemic sclerosis (dcSSc). Patients and methods 28 patients with dcSSc, and 15 age gender matched normal controls were recruited. Skin echogenicity, thickness, and ARFI quantification were measured by ultrasound at 17 sites corresponding to the modified Rodnan skin score (mRSS) in each participant. Compared with controls, skin echogenicity of dcSSc patients was classified into isoechoic, hypoechoic, and hyperechoic. The skin thickness, ARFI quantification and mRSS were compared between isoechoic, hypoechoic, hyperechoic and controls. Results In patients with dcSSc, the skin thickness increased as the echogenicity changed on the order of isoechoic, hypoechoic and hyperechoic. ARFI quantification was significantly higher in hyperechoic than isoechoic (p<0.001). The mRSS were significantly higher in hyperechoic and/or hypoechoic than isoechoic. For isoechoic patients and healthy controls, the skin echogenicity or thickness was no significant different, however, the ARFI quantification was significantly higher in isoechoic than controls. Conclusion Skin ultrasound is feasible for assessing the skin involvement in dcSSc. Skin echogenicity correlates with skin thickness, stiffness, and mRSS. ARFI quantification may be more sensitive to detect skin changes, compared with skin echogenicity and thickness.