SULFUR RADICALS FORMED BY CUTTING ALPHA-KERATIN
SULFUR RADICALS FORMED BY CUTTING ALPHA-KERATIN
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DOI：
10.1038/328833a0
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发表时间：
1987-08-27
期刊：
影响因子：
64.8
通讯作者：
SYMONS, MCR
中科院分区：
文献类型：
--
作者：
CHANDRA, H;SYMONS, MCR
指甲主要由α-角蛋白组成，这是一种蛋白质，其中三个右手α-螺旋肽链被扭曲成一个左手螺旋，并通过二硫键交联加强。我们已经发现，剪指甲的行为会产生被捕获的自由基，产生强烈的电子自旋共振（ESR）信号，这是硫中心自由基的特征。初级自由基的性质和可能的生成模式进行了讨论。当使用人指甲碎片来估计电离辐射意外照射时，应考虑这些自由基反应。
Finger nails are composed largely ofα-keratin, a protein in which three right-handedα-helical peptide chains are twisted into a left-handed coil strengthened by disulphide cross links. We have found that the act of cutting nails generates trapped radicals, giving intense electron spin resonance (ESR) signals characteristic of sulphur centred radicals. The nature of the primary radical and the possible modes of generation are discussed. These radical reactions should be considered when using human nail parings to estimate accidental exposure to ionizing radiation.