Didanosine (ddI) and zidovudine (ZDV) susceptibilities of human immunodeficiency virus (HIV) isolates from long-term recipients of ddI.
Didanosine (ddI) and zidovudine (ZDV) susceptibilities of human immunodeficiency virus (HIV) isolates from long-term recipients of ddI.
复制标题
长期接受 ddI 的人分离出的人类免疫缺陷病毒 (HIV) 对去羟肌苷 (ddI) 和齐多夫定 (ZDV) 的敏感性。
DOI：
10.1016/0166-3542(93)90071-p
复制
发表时间：
1993
影响因子：
7.6
通讯作者：
Dolin,R
中科院分区：
文献类型：
--
作者：
Reichman,RC;Tejani,N;Lambert,JL;Strussenberg,J;Bonnez,W;Blumberg,B;Epstein,L;Dolin,R
30个HIV分离株，从15例患者接受单药治疗前和治疗后与去羟肌苷（ddI），进行了检查的敏感性ddI和齐多夫定（ZDV）使用外周血单核细胞（PBML）为基础的分析。14名患者患有ARC，1名患有AIDS，12名患者既往接受过ZDV治疗。经过中位数为1年的ddI治疗，分离株对ddI的敏感性显着低于治疗前获得的分离株（P= 0.03）。在15个分离株对中的10个中观察到ddI灵敏度降低。与ddI敏感性相反，在同一时间段内，对ZDV的敏感性增加（P= 0.03）。从接受ddI单药治疗2年的4例患者中获得了额外的分离株。其中3株分离株的ddI灵敏度与基线相比无变化。在这项研究中，ddI敏感性降低与血清p24水平、CD4计数或临床结局之间无相关性。从长期接受ddI的HIV分离株中经常发生ddI敏感性降低。这种灵敏度降低程度适中，临床意义未知。
Thirty HIV isolates, obtained from 15 patients before and after receiving single drug therapy with didanosine (ddI), were examined for sensitivity to ddI and zidovudine (ZDV) using a peripheral blood mononuclear leukocyte (PBML)-based assay. Fourteen of the patients had ARC, one had AIDS and 12 had received previous therapy with ZDV. After a median of 1 year of ddI therapy, isolates were significantly less sensitive to ddI than were isolates obtained prior to therapy (P= 0.03). A decrease in ddI sensitivity was observed in ten of the 15 isolate pairs. In contrast to ddI susceptibilities, sensitivity to ZDV increased over the same period of time (P= 0.03). Additional isolates were obtained from four patients who received ddI monotherapy for 2 years. Three of these isolates demonstrated no change in ddI sensitivity compared to baseline. No correlation could be made in this study between development of decreased ddI sensitivity and serum p24 levels, CD4 counts, or clinical outcome. Decreased ddI sensitivity occurs frequently among HIV isolates obtained from long-term recipients of ddI. This decreased sensitivity is modest in degree and is of unknown clinical significance.
登录
查看更多内容
儿童 HIV-1 对齐多夫定的敏感性和临床结果
DOI：
10.1016/0140-6736(92)90140-x
发表时间：
1992
期刊：
The Lancet
影响因子：
--
作者：
G. Tudor;R. McKinney;E. Walter;S. Santacroce;Karen O'Donnell;Wilfert Cm;T. Rudoll;M. H. S. Clair;M. Maha;C. Vavro;M. Mintz;E. Connor
通讯作者：
E. Connor
影响因子：
56.9
作者：
LARDER, BA;KEMP, SD
通讯作者：
KEMP, SD
影响因子：
168.9
作者：
BOUCHER, CAB;TERSMETTE, M;LARDER, BA
通讯作者：
LARDER, BA
使用定量空斑减少测定法测定齐多夫定敏感和耐药的人类免疫缺陷病毒分离株对抗病毒药物的敏感性
影响因子：
4.9
作者：
B. Larder;'. B. Chesebro;D. Richman
通讯作者：
D. Richman
一种简单的高分辨率程序，用于研究高等真核生物中单拷贝基因水平的 DNA 甲基化和体内 DNA-蛋白质相互作用。
DOI：
--
发表时间：
1989
影响因子：
11.1
作者：
Hanspeter Saluz;Jean
通讯作者：
Jean