Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer.
Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer.
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癌症中代谢重编程和表观遗传修饰的相互调节
DOI：
10.3389/fgene.2018.00394
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发表时间：
2018
影响因子：
3.7
通讯作者：
Li S
中科院分区：
文献类型：
--
作者：
Yu X;Ma R;Wu Y;Zhai Y;Li S
癌细胞重新编程其代谢以满足其生存和增殖的需求。肿瘤细胞的代谢可塑性帮助它们适应微环境中营养物质的可用性和利用率的变化。近年来的研究发现，许多代谢物和代谢酶具有非代谢性功能，与肿瘤的发生有关。一个主要功能是调节表观遗传修饰，以促进对环境线索的适当反应。越来越多的证据表明，表观遗传修饰可以反过来改变肿瘤的代谢。虽然对癌症中代谢和表观遗传重新布线之间的相互联系缺乏全面的了解，但已经取得了一些概念性进展。了解癌细胞中代谢和表观遗传修饰之间的联系将有助于开发更有效的癌症疗法。
Cancer cells reprogram their metabolism to meet their demands for survival and proliferation. The metabolic plasticity of tumor cells help them adjust to changes in the availability and utilization of nutrients in the microenvironment. Recent studies revealed that many metabolites and metabolic enzymes have non-metabolic functions contributing to tumorigenesis. One major function is regulating epigenetic modifications to facilitate appropriate responses to environmental cues. Accumulating evidence showed that epigenetic modifications could in turn alter metabolism in tumors. Although a comprehensive understanding of the reciprocal connection between metabolic and epigenetic rewiring in cancer is lacking, some conceptual advances have been made. Understanding the link between metabolism and epigenetic modifications in cancer cells will shed lights on the development of more effective cancer therapies.