PRAZOSIN, AN ALPHA-1-ADRENERGIC RECEPTOR ANTAGONIST, SUPPRESSES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN THE LEWIS RAT
PRAZOSIN, AN ALPHA-1-ADRENERGIC RECEPTOR ANTAGONIST, SUPPRESSES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS IN THE LEWIS RAT
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DOI：
10.1073/pnas.82.17.5915
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发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
NORTON, WT
中科院分区：
文献类型：
--
作者：
BROSNAN, CF;GOLDMUNTZ, EA;NORTON, WT
哌唑嗪是一种α1肾上腺素能受体拮抗剂，已被发现可抑制Lewis大鼠实验性自身免疫性脑脊髓炎(EAE)的临床和组织学表达。抑制在女性中比在男性中更显著，并且是一种剂量依赖的现象。对其他肾上腺素能受体拮抗剂的效果分析支持这样的结论，即哌唑嗪的抑制作用是由于α2受体拮抗剂育亨宾或β受体拮抗剂心得安治疗加重了疾病，而长效的α1/α2拮抗剂苯氧苄明有一定的抑制作用。在过继移植活化的脾或淋巴结细胞致敏的动物中，哌唑嗪治疗也能够抑制EAE的临床和组织学征象。哌唑嗪是否通过改变血管通透性或免疫反应发挥作用，或两者兼而有之，仍有待确定。
Prazosin, an antagonist of alpha 1-adrenergic receptors, has been found to suppress the clinical and histological expression of experimental autoimmune encephalomyelitis (EAE) in the Lewis rat. Suppression was more significant in females than in males and was a dose-dependent phenomenon. Analysis of the effect of other adrenergic receptor antagonists supports the conclusion that the suppressive effect of prazosin is a consequence of blockade of the alpha 1-receptor since treatment with either the alpha 2-antagonist yohimbine or the beta-antagonist propranolol exacerbated the disease, whereas treatment with the long-acting mixed alpha 1/alpha 2-antagonist phenoxybenzamine had some suppressive activity. Treatment with prazosin was also able to suppress clinical and histological signs of EAE in animals sensitized by adoptive transfer with activated spleen or lymph node cells. Whether prazosin acts through altering vascular permeability or the immune response, or both, remains to be determined.