Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with H-1 magnetic resonance spectroscopic imaging
Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with H-1 magnetic resonance spectroscopic imaging
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DOI：
10.1001/archneur.1996.00550020079018
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发表时间：
1996-02-01
影响因子：
--
通讯作者：
Weiner, MW
中科院分区：
文献类型：
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作者：
MacKay, S;Meyerhoff, DJ;Weiner, MW
目的：利用 H-1 磁共振波谱成像研究阿尔茨海默病 (AD)、皮质下缺血性血管性痴呆 (SIVD) 受试者和老年对照受试者神经元密度（N-乙酰天冬氨酸 [NAA]）、膜磷脂代谢物（胆碱 [Cho]）和含肌酸代谢物（肌酸加磷酸肌酸 [Cr]）的差异。设计：横断面，组间。设置：A退伍军人事务医疗中心和大学记忆诊所。 参与者： 40 名患有 AD（n=14）、患有 SIVD（n=8） 的老年受试者和老年对照者（n=18）。 主要结果测量： 我们使用 H-1 磁共振波谱成像从侧脑室上方的 80X100X17-mm 体积中获取波谱。使用核磁共振-1 分析前、中、后灰质和白质体素的光谱，并使用重复测量方差分析 (ANOVA)、Tukey 检验和个体 Student t 检验对组间结果进行比较。结果：使用 ANOVA，在 AD 受试者的灰质和白质体素中观察到 NAA/Cho 和 NAA/Cr 水平显着降低，Cho/Cr 水平显着升高。使用个体学生 t 检验，在 AD 受试者的后灰质中观察到显着较低水平的 NAA/Cho 和较高水平的 Cho/Cr。对 SIVD 受试者进行方差分析，观察到灰质和白质 NAA/Cr 水平显着降低。使用 Tukey 检验，与对照组相比，SIVD 受试者额叶白质体素中的 NAA/Cr 水平显着降低。结论：我们在 AD 受试者中的研究结果表明灰质中的神经元丢失、白质中的轴突丢失以及后脑区域的 Cho 代谢改变。我们在 SIVD 受试者中的研究结果与额叶白质中较高水平的含肌酸代谢物和/或较低水平的 NAA 一致。
Objective: To use H-1 magnetic resonance spectroscopic imaging to study differences in neuron density (N-acetylaspartate [NAA]), membrane phospholipid metabolites (choline [Cho]), and creatine-containing metabolites (creatine plus phosphocreatine [Cr]) in subjects with Alzheimer's disease (AD), with subcortical ischemic vascular dementia (SIVD), and elderly controls.Design: Cross-sectional, between groups.Setting: A Veterans Affairs medical center and university memory clinic.Participants: Forty elderly subjects with AD (n=14), with SIVD (n=8), and elderly controls (n=18).Main Outcome Measures: We used H-1 magnetic resonance spectroscopic imaging to acquire spectra from a 80X100X17-mm volume superior to the lateral ventricles. Spectra were analyzed from voxels in anterior, medial, and posterior gray and white matter using nuclear magnetic resonance-1 and the results were compared between groups using repeated measures analysis of variance (ANOVA), Tukey's test, and individual Student's t tests.Results: Using ANOVA, significantly lower levels of NAA/ Cho and NAA/Cr and significantly higher levels of Cho/Cr were observed across both gray and white matter voxels in subjects with AD. Using individual Student's t tests, a significantly lower level of NAA/Cho and a higher level of Cho/Cr were observed in the posterior gray matter in subjects with AD. Using ANOVA in subjects with SIVD, significantly lower gray and white matter NAA/Cr levels were observed. Using Tukey's test, the NAA/Cr level was significantly lower in frontal white matter voxels in subjects with SIVD compared with controls.Conclusions: Our findings in subjects with AD suggest neuron loss in gray matter, axon loss in white matter, and altered Cho metabolism in posterior brain regions. Our findings in subjects with SIVD are consistent with higher levels of creatine-containing metabolites and/or lower levels of NAA in frontal white matter.