JAK-STAT and the renin-angiotensin system: The role of the JAK-STAT pathway in blood pressure and intrarenal renin-angiotensin system regulation.
JAK-STAT and the renin-angiotensin system: The role of the JAK-STAT pathway in blood pressure and intrarenal renin-angiotensin system regulation.
复制标题
JAK-STAT和肾素 - 血管紧张素系统：JAK-STAT途径在血压和肾上腺内血管紧张素系统调节中的作用。
DOI：
10.4161/jkst.22729
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发表时间：
2012-10-01
期刊：
影响因子：
--
通讯作者：
Gonzalez-Villalobos RA
中科院分区：
文献类型：
--
作者：
Satou R;Gonzalez-Villalobos RA
肾素-血管紧张素系统（RAS）在血压控制和组织疾病中起重要作用。肾脏中不适当的局部血管紧张素II升高导致高血压、组织损伤和慢性损伤的发展。研究表明JAK-STAT通路介导血管紧张素II触发的基因转录。JAK-STAT通路反过来作为一个放大系统，有助于进一步肾内RAS激活。这些观察提示JAK-STAT通路可能在阐明RAS相关组织损伤机制中具有重要意义。因此，本文综述了JAK-STAT通路与RAS之间的相互作用，特别是肾脏中表达的RAS。
The renin-angiotensin system (RAS) plays important roles in blood pressure control and tissue disease. An inappropriate local angiotensin II elevation in the kidneys leads to the development of hypertension, tissue damage and chronic injury. Studies have demonstrated that the JAK-STAT pathway mediates angiotensin II-triggered gene transcription. The JAK-STAT pathway in turn, acting as an amplifying system, contributes to further intrarenal RAS activation. These observations prompt the suggestion that the JAK-STAT pathway may be of importance in elucidating the mechanisms RAS-associated tissue injury. Accordingly, this review provides a brief overview of the interactions between the JAK-STAT pathway and the RAS, specifically the RAS expressed in the kidneys.